Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels

Drug release kinetics in two compositions of methacrylate hydrogels were monitored as a function of the hydrogel and drug molecular weight. Through modifying the molecular weight of hydrogels, it was demonstrated how the release could be tuned, allowing for increased stability of hydrogels and enhan...

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Autores principales: Toews, Parker, Bates, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550905/
https://www.ncbi.nlm.nih.gov/pubmed/37794078
http://dx.doi.org/10.1038/s41598-023-42923-3
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author Toews, Parker
Bates, Jeffrey
author_facet Toews, Parker
Bates, Jeffrey
author_sort Toews, Parker
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description Drug release kinetics in two compositions of methacrylate hydrogels were monitored as a function of the hydrogel and drug molecular weight. Through modifying the molecular weight of hydrogels, it was demonstrated how the release could be tuned, allowing for increased stability of hydrogels and enhanced release performance. Spectroscopy techniques such as FTIR and UV–Vis–NIR provided inferences into the chemical structure, target molecule concentration, and optical performance of the studied hydrogels. By studying the 30-day target molecule loading stability of the hydrogels, a relationship between the drug and hydrogel molecular weight, and the drug release kinetics could be determined.
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spelling pubmed-105509052023-10-06 Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels Toews, Parker Bates, Jeffrey Sci Rep Article Drug release kinetics in two compositions of methacrylate hydrogels were monitored as a function of the hydrogel and drug molecular weight. Through modifying the molecular weight of hydrogels, it was demonstrated how the release could be tuned, allowing for increased stability of hydrogels and enhanced release performance. Spectroscopy techniques such as FTIR and UV–Vis–NIR provided inferences into the chemical structure, target molecule concentration, and optical performance of the studied hydrogels. By studying the 30-day target molecule loading stability of the hydrogels, a relationship between the drug and hydrogel molecular weight, and the drug release kinetics could be determined. Nature Publishing Group UK 2023-10-04 /pmc/articles/PMC10550905/ /pubmed/37794078 http://dx.doi.org/10.1038/s41598-023-42923-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Toews, Parker
Bates, Jeffrey
Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title_full Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title_fullStr Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title_full_unstemmed Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title_short Influence of drug and polymer molecular weight on release kinetics from HEMA and HPMA hydrogels
title_sort influence of drug and polymer molecular weight on release kinetics from hema and hpma hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550905/
https://www.ncbi.nlm.nih.gov/pubmed/37794078
http://dx.doi.org/10.1038/s41598-023-42923-3
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