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Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans

Achieving healthy aging and providing protection from aging-related diseases is a major global concern. Probiotics, are a safer and more natural alternative. Moreover, identifying novel probiotics can help develop a new therapeutic approach and may help in personalized probiotic-formulations for ind...

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Autores principales: Kumaree, Kishoree K., Prasanth, Mani Iyer, Sivamaruthi, Bhagavathi Sundaram, Kesika, Periyanaina, Tencomnao, Tewin, Chaiyasut, Chaiyavat, Prasansuklab, Anchalee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550917/
https://www.ncbi.nlm.nih.gov/pubmed/37794096
http://dx.doi.org/10.1038/s41598-023-43846-9
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author Kumaree, Kishoree K.
Prasanth, Mani Iyer
Sivamaruthi, Bhagavathi Sundaram
Kesika, Periyanaina
Tencomnao, Tewin
Chaiyasut, Chaiyavat
Prasansuklab, Anchalee
author_facet Kumaree, Kishoree K.
Prasanth, Mani Iyer
Sivamaruthi, Bhagavathi Sundaram
Kesika, Periyanaina
Tencomnao, Tewin
Chaiyasut, Chaiyavat
Prasansuklab, Anchalee
author_sort Kumaree, Kishoree K.
collection PubMed
description Achieving healthy aging and providing protection from aging-related diseases is a major global concern. Probiotics, are a safer and more natural alternative. Moreover, identifying novel probiotics can help develop a new therapeutic approach and may help in personalized probiotic-formulations for individual's unique gut microbiome. In this study, we evaluated the benefits of our novel probiotic strains in promoting healthy aging and whether they protect against Amyloid β toxicity of Alzheimer's disease. Henceforth, we analyzed the impact of four different probiotics (Lactobacillus paracasei HII01, L. rhamnosus, L. reuteri, L. salivarius) on the lifespan extension of Caenorhabditis elegans model. Our results determine that L. paracasei HII01 provided the most positive effect on longevity and antiaging effects on C. elegans. The qPCR data and mutant-based studies indicated that L. paracasei HII01-mediated lifespan extension could be modulated by DAF-16 mediated pathway. The probiotic strains also protected the worms from the toxicity induced by β-Amyloid-expressing (Aβ) transgenic C. elegans strains, and L. paracasei HII01 provided the most significant protection. Overall, identifying novel probiotics is an important area of research that can improve health outcomes. Our study showed that L. paracasei HII01 could be considered a dietary supplement for providing healthy aging and preventing aging-related diseases.
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spelling pubmed-105509172023-10-06 Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans Kumaree, Kishoree K. Prasanth, Mani Iyer Sivamaruthi, Bhagavathi Sundaram Kesika, Periyanaina Tencomnao, Tewin Chaiyasut, Chaiyavat Prasansuklab, Anchalee Sci Rep Article Achieving healthy aging and providing protection from aging-related diseases is a major global concern. Probiotics, are a safer and more natural alternative. Moreover, identifying novel probiotics can help develop a new therapeutic approach and may help in personalized probiotic-formulations for individual's unique gut microbiome. In this study, we evaluated the benefits of our novel probiotic strains in promoting healthy aging and whether they protect against Amyloid β toxicity of Alzheimer's disease. Henceforth, we analyzed the impact of four different probiotics (Lactobacillus paracasei HII01, L. rhamnosus, L. reuteri, L. salivarius) on the lifespan extension of Caenorhabditis elegans model. Our results determine that L. paracasei HII01 provided the most positive effect on longevity and antiaging effects on C. elegans. The qPCR data and mutant-based studies indicated that L. paracasei HII01-mediated lifespan extension could be modulated by DAF-16 mediated pathway. The probiotic strains also protected the worms from the toxicity induced by β-Amyloid-expressing (Aβ) transgenic C. elegans strains, and L. paracasei HII01 provided the most significant protection. Overall, identifying novel probiotics is an important area of research that can improve health outcomes. Our study showed that L. paracasei HII01 could be considered a dietary supplement for providing healthy aging and preventing aging-related diseases. Nature Publishing Group UK 2023-10-04 /pmc/articles/PMC10550917/ /pubmed/37794096 http://dx.doi.org/10.1038/s41598-023-43846-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kumaree, Kishoree K.
Prasanth, Mani Iyer
Sivamaruthi, Bhagavathi Sundaram
Kesika, Periyanaina
Tencomnao, Tewin
Chaiyasut, Chaiyavat
Prasansuklab, Anchalee
Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title_full Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title_fullStr Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title_full_unstemmed Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title_short Lactobacillus paracasei HII01 enhances lifespan and promotes neuroprotection in Caenorhabditis elegans
title_sort lactobacillus paracasei hii01 enhances lifespan and promotes neuroprotection in caenorhabditis elegans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550917/
https://www.ncbi.nlm.nih.gov/pubmed/37794096
http://dx.doi.org/10.1038/s41598-023-43846-9
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