Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

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Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of biological functions. In particular, the T cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, -3, -4) decorate immune cells and act as key regulators in cellular immunity. However, thei...

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Detalles Bibliográficos
Autores principales: Chongsaritsinsuk, Joann, Steigmeyer, Alexandra D., Mahoney, Keira E., Rosenfeld, Mia A., Lucas, Taryn M., Smith, Courtney M., Li, Alice, Ince, Deniz, Kearns, Fiona L., Battison, Alexandria S., Hollenhorst, Marie A., Judy Shon, D., Tiemeyer, Katherine H., Attah, Victor, Kwon, Catherine, Bertozzi, Carolyn R., Ferracane, Michael J., Lemmon, Mark A., Amaro, Rommie E., Malaker, Stacy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550946/
https://www.ncbi.nlm.nih.gov/pubmed/37794035
http://dx.doi.org/10.1038/s41467-023-41756-y
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