Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines

COVID-19 vaccines were originally designed based on the ancestral Spike protein, but immune escape of emergent Variants of Concern (VOC) jeopardized their efficacy, warranting variant-proof vaccines. Here, we used preclinical rodent models to establish the cross-protective and cross-neutralizing cap...

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Detalles Bibliográficos
Autores principales: Vinzón, Sabrina E., Lopez, María V., Cafferata, Eduardo G. A., Soto, Ariadna S., Berguer, Paula M., Vazquez, Luciana, Nusblat, Leonora, Pontoriero, Andrea V., Belotti, Eduardo M., Salvetti, Natalia R., Viale, Diego L., Vilardo, Ariel E., Avaro, Martin M., Benedetti, Estefanía, Russo, Mara L., Dattero, María E., Carobene, Mauricio, Sánchez-Lamas, Maximiliano, Afonso, Jimena, Heitrich, Mauro, Cristófalo, Alejandro E., Otero, Lisandro H., Baumeister, Elsa G., Ortega, Hugo H., Edelstein, Alexis, Podhajcer, Osvaldo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10550992/
https://www.ncbi.nlm.nih.gov/pubmed/37794010
http://dx.doi.org/10.1038/s41541-023-00737-4

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