Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines

Evolution of human H3N2 influenza viruses driven by immune selection has narrowed the receptor specificity of the hemagglutinin (HA) to a restricted subset of human-type (Neu5Acα2-6 Gal) glycan receptors that have extended poly-LacNAc (Galβ1-4GlcNAc) repeats. This altered specificity has presented c...

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Detalles Bibliográficos
Autores principales: Kikuchi, Chika, Antonopoulos, Aristotelis, Wang, Shengyang, Maemura, Tadashi, Karamanska, Rositsa, Lee, Chiara, Thompson, Andrew J., Dell, Anne, Kawaoka, Yoshihiro, Haslam, Stuart M., Paulson, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551000/
https://www.ncbi.nlm.nih.gov/pubmed/37794004
http://dx.doi.org/10.1038/s41467-023-41908-0

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