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Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia

Lymphatic filariasis (LF) and onchocerciasis (OV) are among the neglected tropical diseases (NTD) targeted for elimination in Ethiopia. We used a transmission assessment survey (TAS-1) to evaluate the serological status of OV in three co-endemic districts in Gambella simultaneously. During May and J...

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Autores principales: Hassen, Mohammed, Mohammed, Aderajew, Endeshaw, Tekola, Seid, Tewodros, Samuel, Fikresilasie, Asmare, Tadese, Birhanu, Henok, Bekele, Firdaweke, Yayeh, Adane, Seife, Fikre, Tamiru, Mossie, Meribo, Kadu, Tadesse, Zerihun, Griswold, Emily, Katabarwa, Moses, Richards, Frank, Noland, Gregory S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551079/
https://www.ncbi.nlm.nih.gov/pubmed/37696513
http://dx.doi.org/10.4269/ajtmh.22-0392
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author Hassen, Mohammed
Mohammed, Aderajew
Endeshaw, Tekola
Seid, Tewodros
Samuel, Fikresilasie
Asmare, Tadese
Birhanu, Henok
Bekele, Firdaweke
Yayeh, Adane
Seife, Fikre
Tamiru, Mossie
Meribo, Kadu
Tadesse, Zerihun
Griswold, Emily
Katabarwa, Moses
Richards, Frank
Noland, Gregory S.
author_facet Hassen, Mohammed
Mohammed, Aderajew
Endeshaw, Tekola
Seid, Tewodros
Samuel, Fikresilasie
Asmare, Tadese
Birhanu, Henok
Bekele, Firdaweke
Yayeh, Adane
Seife, Fikre
Tamiru, Mossie
Meribo, Kadu
Tadesse, Zerihun
Griswold, Emily
Katabarwa, Moses
Richards, Frank
Noland, Gregory S.
author_sort Hassen, Mohammed
collection PubMed
description Lymphatic filariasis (LF) and onchocerciasis (OV) are among the neglected tropical diseases (NTD) targeted for elimination in Ethiopia. We used a transmission assessment survey (TAS-1) to evaluate the serological status of OV in three co-endemic districts in Gambella simultaneously. During May and June 2019, blood samples were collected from 6- to 7-year-old children who were randomly selected through standard community-based TAS methodology. Children were tested for both circulating filarial antigen (CFA) for LF via filariasis test strip and for Onchocerca volvulus 16 (Ov16) antibody for OV via laboratory-based ELISA. A total of 3,377 children from 150 villages in the three districts were tested; 1,823 (54.0%) were male. All three districts had CFA results below the critical threshold for stopping LF mass drug administration (MDA). In contrast, 40 children (1.2%) were positive for Ov16 antibody, well above the WHO’s OV stop MDA threshold of 0.1%. The integrated assessment indicated two programmatic decisions: stop MDA for LF and continue MDA for OV. Accordingly, albendazole MDA was discontinued in the districts but ivermectin MDA continued. This integrated assessment showed that a random sample for TAS can give important information about OV transmission status in co-endemic areas.
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spelling pubmed-105510792023-10-06 Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia Hassen, Mohammed Mohammed, Aderajew Endeshaw, Tekola Seid, Tewodros Samuel, Fikresilasie Asmare, Tadese Birhanu, Henok Bekele, Firdaweke Yayeh, Adane Seife, Fikre Tamiru, Mossie Meribo, Kadu Tadesse, Zerihun Griswold, Emily Katabarwa, Moses Richards, Frank Noland, Gregory S. Am J Trop Med Hyg Research Article Lymphatic filariasis (LF) and onchocerciasis (OV) are among the neglected tropical diseases (NTD) targeted for elimination in Ethiopia. We used a transmission assessment survey (TAS-1) to evaluate the serological status of OV in three co-endemic districts in Gambella simultaneously. During May and June 2019, blood samples were collected from 6- to 7-year-old children who were randomly selected through standard community-based TAS methodology. Children were tested for both circulating filarial antigen (CFA) for LF via filariasis test strip and for Onchocerca volvulus 16 (Ov16) antibody for OV via laboratory-based ELISA. A total of 3,377 children from 150 villages in the three districts were tested; 1,823 (54.0%) were male. All three districts had CFA results below the critical threshold for stopping LF mass drug administration (MDA). In contrast, 40 children (1.2%) were positive for Ov16 antibody, well above the WHO’s OV stop MDA threshold of 0.1%. The integrated assessment indicated two programmatic decisions: stop MDA for LF and continue MDA for OV. Accordingly, albendazole MDA was discontinued in the districts but ivermectin MDA continued. This integrated assessment showed that a random sample for TAS can give important information about OV transmission status in co-endemic areas. The American Society of Tropical Medicine and Hygiene 2023-09-11 2023-10 /pmc/articles/PMC10551079/ /pubmed/37696513 http://dx.doi.org/10.4269/ajtmh.22-0392 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Hassen, Mohammed
Mohammed, Aderajew
Endeshaw, Tekola
Seid, Tewodros
Samuel, Fikresilasie
Asmare, Tadese
Birhanu, Henok
Bekele, Firdaweke
Yayeh, Adane
Seife, Fikre
Tamiru, Mossie
Meribo, Kadu
Tadesse, Zerihun
Griswold, Emily
Katabarwa, Moses
Richards, Frank
Noland, Gregory S.
Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title_full Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title_fullStr Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title_full_unstemmed Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title_short Integrated Prevalence Assessment of Wuchereria bancrofti and Onchocerca volvulus in Three Co-Endemic Districts of Gambella Region, Ethiopia
title_sort integrated prevalence assessment of wuchereria bancrofti and onchocerca volvulus in three co-endemic districts of gambella region, ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551079/
https://www.ncbi.nlm.nih.gov/pubmed/37696513
http://dx.doi.org/10.4269/ajtmh.22-0392
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