TRAIL promotes the polarization of human macrophages toward a proinflammatory M1 phenotype and is associated with increased survival in cancer patients with high tumor macrophage content

BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can either induce cell death or activate survival pathways after binding to death receptors (DRs) DR4 or DR5. TRAIL is investigated as a therapeutic agent in clinical trials due to its selective toxicit...

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Detalles Bibliográficos
Autores principales: Gunalp, Sinem, Helvaci, Derya Goksu, Oner, Aysenur, Bursalı, Ahmet, Conforte, Alessandra, Güner, Hüseyin, Karakülah, Gökhan, Szegezdi, Eva, Sag, Duygu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551148/
https://www.ncbi.nlm.nih.gov/pubmed/37809073
http://dx.doi.org/10.3389/fimmu.2023.1209249

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