Dual Immune Checkpoint Blockade Induces Analogous Alterations in the Dysfunctional CD8(+) T-cell and Activated Treg Compartment

To dissect the effect of neoadjuvant PD-1 and CTLA4 blockade on intratumoral T cells in treatment-naive head and neck squamous cell carcinoma, we analyzed primary tumor immune infiltrates from responding and nonresponding patients. At baseline, a higher ratio between active (4-1BB/OX40(+)) and inact...

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Detalles Bibliográficos
Autores principales: van der Leun, Anne M., Traets, Joleen J.H., Vos, Joris L., Elbers, Joris B.W., Patiwael, Sanne, Qiao, Xiaohang, Machuca-Ostos, Mercedes, Thommen, Daniela S., Haanen, John B.A.G., Schumacher, Ton N.M., Zuur, Charlotte L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551666/
https://www.ncbi.nlm.nih.gov/pubmed/37548431
http://dx.doi.org/10.1158/2159-8290.CD-22-0851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551666/
https://www.ncbi.nlm.nih.gov/pubmed/37548431
http://dx.doi.org/10.1158/2159-8290.CD-22-0851

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