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The novel β-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer

Trastuzumab notably improves the outcome of human epidermal growth factor receptor 2 (HER2)-positive breast cancer patients, however, resistance to trastuzumab remains a major hurdle to clinical treatment. In the present study, we identify a circular RNA intimately linked to trastuzumab resistance....

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Detalles Bibliográficos
Autores principales: Wang, Shengting, Wang, Yufang, Li, Qian, Li, Xiaoming, Feng, Xinghua, Zeng, Kaixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551893/
https://www.ncbi.nlm.nih.gov/pubmed/37783059
http://dx.doi.org/10.1016/j.redox.2023.102896