Endogenous Rab38 regulates LRRK2’s membrane recruitment and substrate Rab phosphorylation in melanocytes

Point mutations in leucine-rich repeat kinase 2 (LRRK2) cause Parkinson’s disease and augment LRRK2’s kinase activity. However, cellular pathways that endogenously enhance LRRK2 kinase function have not been identified. While overexpressed Rab29 draws LRRK2 to Golgi membranes to increase LRRK2 kinas...

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Detalles Bibliográficos
Autores principales: Unapanta, Alexandra, Shavarebi, Farbod, Porath, Jacob, Shen, Yiyi, Balen, Carson, Nguyen, Albert, Tseng, Josh, Leong, Weng Si, Liu, Michelle, Lis, Pawel, Di Pietro, Santiago M., Hiniker, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551901/
https://www.ncbi.nlm.nih.gov/pubmed/37625589
http://dx.doi.org/10.1016/j.jbc.2023.105192

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