Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

In several long-lived Caenorhabditis elegans strains, such as insulin/IGF-1 receptor daf-2 mutants, enhanced proteostatic mechanisms are accompanied by elevated intestinal lipid stores, but their role in longevity is unclear. Here, while determining the regulatory network of the selective autophagy...

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Detalles Bibliográficos
Autores principales: Kumar, Anita V., Mills, Joslyn, Parker, Wesley M., Leitão, Joshua A., Rodriguez, Diego I., Daigle, Sandrine E., Ng, Celeste, Patel, Rishi, Aguilera, Joseph L., Johnson, Joseph R., Wong, Shi Quan, Lapierre, Louis R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551902/
https://www.ncbi.nlm.nih.gov/pubmed/37810233
http://dx.doi.org/10.1016/j.isci.2023.107960

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