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Phase separation promotes a highly active oligomeric scaffold of the MLL1 core complex for regulation of histone H3K4 methylation

Enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation are crucial for proper cellular differentiation and are frequently mutated in cancer. The Mixed lineage leukemia (MLL) family of enzymes deposit H3K4 mono-, di-, or trimethylation at distinct genomic locations, requiring prec...

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Detalles Bibliográficos
Autores principales:	Namitz, Kevin E.W., Showalter, Scott A., Cosgrove, Michael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551905/ https://www.ncbi.nlm.nih.gov/pubmed/37660926 http://dx.doi.org/10.1016/j.jbc.2023.105204

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