SGN-B7H4V, an investigational vedotin ADC directed to the immune checkpoint ligand B7-H4, shows promising activity in preclinical models

BACKGROUND: SGN-B7H4V is a novel investigational vedotin antibody–drug conjugate (ADC) comprising a B7-H4-directed human monoclonal antibody conjugated to the cytotoxic payload monomethyl auristatin E (MMAE) via a protease-cleavable maleimidocaproyl valine citrulline (mc-vc) linker. This vedotin lin...

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Detalles Bibliográficos
Autores principales: Gray, Elizabeth, Ulrich, Michelle, Epp, Angela, Younan, Patrick, Sahetya, Disha, Hensley, Kelly, Allred, Sean, Huang, Li-Ya, Hahn, Julie, Gahnberg, Kristen, Treuting, Piper M, Trueblood, Esther S, Gosink, John J, Thurman, Robert, Wo, Serena, Spahr, Kellie, Haass, Evgenia Jane, Snead, Katie, Miller, Dannah, Padilla, Mary, Smith, Alyson J, Frantz, Chris, Schrum, Jason P, Nazarenko, Natalya, Gardai, Shyra J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551938/
https://www.ncbi.nlm.nih.gov/pubmed/37793853
http://dx.doi.org/10.1136/jitc-2023-007572

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