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Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)
PURPOSE: Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The ov...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551950/ https://www.ncbi.nlm.nih.gov/pubmed/37793927 http://dx.doi.org/10.1136/bmjopen-2022-069427 |
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author | Boberg, Julia Kaldo, Viktor Mataix-Cols, David Crowley, James J Roelstraete, Bjorn Halvorsen, Matthew Forsell, Erik Isacsson, Nils H Sullivan, Patrick F Svanborg, Cecilia Andersson, Evelyn H Lindefors, Nils Kravchenko, Olly Mattheisen, Manuel Danielsdottir, Hilda B Ivanova, Ekaterina Boman, Magnus Fernández de la Cruz, Lorena Wallert, John Rück, Christian |
author_facet | Boberg, Julia Kaldo, Viktor Mataix-Cols, David Crowley, James J Roelstraete, Bjorn Halvorsen, Matthew Forsell, Erik Isacsson, Nils H Sullivan, Patrick F Svanborg, Cecilia Andersson, Evelyn H Lindefors, Nils Kravchenko, Olly Mattheisen, Manuel Danielsdottir, Hilda B Ivanova, Ekaterina Boman, Magnus Fernández de la Cruz, Lorena Wallert, John Rück, Christian |
author_sort | Boberg, Julia |
collection | PubMed |
description | PURPOSE: Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data. PARTICIPANTS: MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029. FINDINGS TO DATE: Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase. FUTURE PLANS: The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for research collaboration. |
format | Online Article Text |
id | pubmed-10551950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-105519502023-10-06 Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) Boberg, Julia Kaldo, Viktor Mataix-Cols, David Crowley, James J Roelstraete, Bjorn Halvorsen, Matthew Forsell, Erik Isacsson, Nils H Sullivan, Patrick F Svanborg, Cecilia Andersson, Evelyn H Lindefors, Nils Kravchenko, Olly Mattheisen, Manuel Danielsdottir, Hilda B Ivanova, Ekaterina Boman, Magnus Fernández de la Cruz, Lorena Wallert, John Rück, Christian BMJ Open Genetics and Genomics PURPOSE: Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data. PARTICIPANTS: MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029. FINDINGS TO DATE: Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase. FUTURE PLANS: The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for research collaboration. BMJ Publishing Group 2023-10-04 /pmc/articles/PMC10551950/ /pubmed/37793927 http://dx.doi.org/10.1136/bmjopen-2022-069427 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Genetics and Genomics Boberg, Julia Kaldo, Viktor Mataix-Cols, David Crowley, James J Roelstraete, Bjorn Halvorsen, Matthew Forsell, Erik Isacsson, Nils H Sullivan, Patrick F Svanborg, Cecilia Andersson, Evelyn H Lindefors, Nils Kravchenko, Olly Mattheisen, Manuel Danielsdottir, Hilda B Ivanova, Ekaterina Boman, Magnus Fernández de la Cruz, Lorena Wallert, John Rück, Christian Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title | Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title_full | Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title_fullStr | Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title_full_unstemmed | Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title_short | Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH) |
title_sort | swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (multi-psych) |
topic | Genetics and Genomics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10551950/ https://www.ncbi.nlm.nih.gov/pubmed/37793927 http://dx.doi.org/10.1136/bmjopen-2022-069427 |
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