Overcoming Challenges in Chemical Glycosylation to Achieve Innovative Vaccine Adjuvants Possessing Enhanced TLR4 Activity

[Image: see text] Lipopolysaccharide (LPS) mimicry leading to toll-like receptor 4 (TLR4) active compounds has been so far based mainly on reproducing the lipid A portion of LPS. Our work led to a series of structurally simplified synthetic TLR4 agonists in preclinical development as vaccine adjuvan...

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Detalles Bibliográficos
Autores principales: Romerio, Alessio, Franco, Ana Rita, Shadrick, Melanie, Shaik, Mohammed Monsoor, Artusa, Valentina, Italia, Alice, Lami, Federico, Demchenko, Alexei V., Peri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552098/
https://www.ncbi.nlm.nih.gov/pubmed/37810727
http://dx.doi.org/10.1021/acsomega.3c05363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552098/
https://www.ncbi.nlm.nih.gov/pubmed/37810727
http://dx.doi.org/10.1021/acsomega.3c05363

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