Chiral Resolution of the Enantiomers of the Slow-Onset Dopamine Reuptake Inhibitor CTDP-32476 and Their Activities

[Image: see text] An improved synthesis was developed for CDTP-32476, a potent slow-onset dopamine reuptake blocker that may have utility as a treatment for cocaine abuse. The enantiomers of the compound were separated by fractional crystallization with N-acetylleucine enantiomers. An X-ray crystal...

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Detalles Bibliográficos
Autores principales: Froimowitz, Mark, Taboada, Rosa, Poulos, Zachary J., Rainone, Dominic J., Imler, Gregory H., Gardner, Eliot L., Kelley, Charles J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552101/
https://www.ncbi.nlm.nih.gov/pubmed/37810691
http://dx.doi.org/10.1021/acsomega.3c02997

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