Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source

[Image: see text] Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl(2)PPh(3)(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiment...

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Detalles Bibliográficos
Autores principales: Gao, Caiyu, Li, Yufei, Wang, Minghao, Gong, Dawei, Zhao, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552110/
https://www.ncbi.nlm.nih.gov/pubmed/37810663
http://dx.doi.org/10.1021/acsomega.3c06260
Descripción
Sumario:[Image: see text] Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl(2)PPh(3)(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiments suggested the reaction via the Ru–H mechanism. This study provides a new ruthenium catalyst system for N-methylation with methanol under weak base conditions.

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