Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source

[Image: see text] Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl(2)PPh(3)(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiment...

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Autores principales: Gao, Caiyu, Li, Yufei, Wang, Minghao, Gong, Dawei, Zhao, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552110/
https://www.ncbi.nlm.nih.gov/pubmed/37810663
http://dx.doi.org/10.1021/acsomega.3c06260
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author Gao, Caiyu
Li, Yufei
Wang, Minghao
Gong, Dawei
Zhao, Lina
author_facet Gao, Caiyu
Li, Yufei
Wang, Minghao
Gong, Dawei
Zhao, Lina
author_sort Gao, Caiyu
collection PubMed
description [Image: see text] Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl(2)PPh(3)(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiments suggested the reaction via the Ru–H mechanism. This study provides a new ruthenium catalyst system for N-methylation with methanol under weak base conditions.
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spelling pubmed-105521102023-10-06 Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source Gao, Caiyu Li, Yufei Wang, Minghao Gong, Dawei Zhao, Lina ACS Omega [Image: see text] Four ruthenium complexes were used as catalysts for the N-methylation of amines using methanol as the C1 source under weak base conditions. The (DPEPhos)RuCl(2)PPh(3)(1a) catalyst showed the best catalytic performance (0.5 mol %, 12 h). The deuterium labeling and control experiments suggested the reaction via the Ru–H mechanism. This study provides a new ruthenium catalyst system for N-methylation with methanol under weak base conditions. American Chemical Society 2023-09-20 /pmc/articles/PMC10552110/ /pubmed/37810663 http://dx.doi.org/10.1021/acsomega.3c06260 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Gao, Caiyu
Li, Yufei
Wang, Minghao
Gong, Dawei
Zhao, Lina
Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title_full Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title_fullStr Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title_full_unstemmed Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title_short Ru(II)-Catalyzed N-Methylation of Amines Using Methanol as the C1 Source
title_sort ru(ii)-catalyzed n-methylation of amines using methanol as the c1 source
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552110/
https://www.ncbi.nlm.nih.gov/pubmed/37810663
http://dx.doi.org/10.1021/acsomega.3c06260
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