Cargando…
cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes
Transplantation is an important life-saving therapeutic choice for patients with organ or tissue failure once all other treatment options are exhausted. However, most allografts become damaged over an extended period, and post-transplantation survival is limited. Ischemia reperfusion injury (IRI) te...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552181/ https://www.ncbi.nlm.nih.gov/pubmed/37809088 http://dx.doi.org/10.3389/fimmu.2023.1231057 |
_version_ | 1785115904857604096 |
---|---|
author | Chen, Zijian Liu, Yangqi Lin, Zeying Huang, Weizhe |
author_facet | Chen, Zijian Liu, Yangqi Lin, Zeying Huang, Weizhe |
author_sort | Chen, Zijian |
collection | PubMed |
description | Transplantation is an important life-saving therapeutic choice for patients with organ or tissue failure once all other treatment options are exhausted. However, most allografts become damaged over an extended period, and post-transplantation survival is limited. Ischemia reperfusion injury (IRI) tends to be associated with a poor prognosis; resultant severe primary graft dysfunction is the main cause of transplant failure. Targeting the cGAS–STING pathway has recently been shown to be an effective approach for improving transplantation outcomes, when activated or inhibited cGAS–STING pathway, IRI can be alleviated by regulating inflammatory response and programmed cell death. Thus, continuing efforts to develop selective agonists and antagonists may bring great hopes to post-transplant patient. In this mini-review, we reviewed the role of the cGAS–STING pathway in transplantation, and summarized the crosstalk between this pathway and inflammatory response and programmed cell death during IRI, aiming to provide novel insights into the development of therapies to improve patient outcome after transplantation. |
format | Online Article Text |
id | pubmed-10552181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105521812023-10-06 cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes Chen, Zijian Liu, Yangqi Lin, Zeying Huang, Weizhe Front Immunol Immunology Transplantation is an important life-saving therapeutic choice for patients with organ or tissue failure once all other treatment options are exhausted. However, most allografts become damaged over an extended period, and post-transplantation survival is limited. Ischemia reperfusion injury (IRI) tends to be associated with a poor prognosis; resultant severe primary graft dysfunction is the main cause of transplant failure. Targeting the cGAS–STING pathway has recently been shown to be an effective approach for improving transplantation outcomes, when activated or inhibited cGAS–STING pathway, IRI can be alleviated by regulating inflammatory response and programmed cell death. Thus, continuing efforts to develop selective agonists and antagonists may bring great hopes to post-transplant patient. In this mini-review, we reviewed the role of the cGAS–STING pathway in transplantation, and summarized the crosstalk between this pathway and inflammatory response and programmed cell death during IRI, aiming to provide novel insights into the development of therapies to improve patient outcome after transplantation. Frontiers Media S.A. 2023-09-21 /pmc/articles/PMC10552181/ /pubmed/37809088 http://dx.doi.org/10.3389/fimmu.2023.1231057 Text en Copyright © 2023 Chen, Liu, Lin and Huang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Chen, Zijian Liu, Yangqi Lin, Zeying Huang, Weizhe cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title | cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title_full | cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title_fullStr | cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title_full_unstemmed | cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title_short | cGAS–STING pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
title_sort | cgas–sting pathway in ischemia-reperfusion injury: a potential target to improve transplantation outcomes |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552181/ https://www.ncbi.nlm.nih.gov/pubmed/37809088 http://dx.doi.org/10.3389/fimmu.2023.1231057 |
work_keys_str_mv | AT chenzijian cgasstingpathwayinischemiareperfusioninjuryapotentialtargettoimprovetransplantationoutcomes AT liuyangqi cgasstingpathwayinischemiareperfusioninjuryapotentialtargettoimprovetransplantationoutcomes AT linzeying cgasstingpathwayinischemiareperfusioninjuryapotentialtargettoimprovetransplantationoutcomes AT huangweizhe cgasstingpathwayinischemiareperfusioninjuryapotentialtargettoimprovetransplantationoutcomes |