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Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report

BACKGROUND: Post-implant right heart failure (RHF) has been recognized as a crucial prognostic factor in patients receiving left ventricular assist devices (LVADs), and its management has long attracted attention from cardiologists and surgeons. CASE PRESENTATION: This report described an 18-year-ol...

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Autores principales: Kunioka, Shingo, Seguchi, Osamu, Hada, Tasuku, Mochizuki, Hiroki, Shimojima, Masaya, Watanabe, Takuya, Tsukamoto, Yasumasa, Tadokoro, Naoki, Kainuma, Satoshi, Fukushima, Satsuki, Fujita, Tomoyuki, Kamiya, Hiroyuki, Fukushima, Norihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552193/
https://www.ncbi.nlm.nih.gov/pubmed/37794433
http://dx.doi.org/10.1186/s13019-023-02368-1
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author Kunioka, Shingo
Seguchi, Osamu
Hada, Tasuku
Mochizuki, Hiroki
Shimojima, Masaya
Watanabe, Takuya
Tsukamoto, Yasumasa
Tadokoro, Naoki
Kainuma, Satoshi
Fukushima, Satsuki
Fujita, Tomoyuki
Kamiya, Hiroyuki
Fukushima, Norihide
author_facet Kunioka, Shingo
Seguchi, Osamu
Hada, Tasuku
Mochizuki, Hiroki
Shimojima, Masaya
Watanabe, Takuya
Tsukamoto, Yasumasa
Tadokoro, Naoki
Kainuma, Satoshi
Fukushima, Satsuki
Fujita, Tomoyuki
Kamiya, Hiroyuki
Fukushima, Norihide
author_sort Kunioka, Shingo
collection PubMed
description BACKGROUND: Post-implant right heart failure (RHF) has been recognized as a crucial prognostic factor in patients receiving left ventricular assist devices (LVADs), and its management has long attracted attention from cardiologists and surgeons. CASE PRESENTATION: This report described an 18-year-old female with acutely deteriorating heart failure due to dilated cardiomyopathy who underwent paracorporeal pulsatile-flow LVAD and developed early post-implant RHF. At postoperative day (POD) six, she was almost asymptomatic at rest on 2.5 mg/kg/min of dobutamine; however, the echocardiogram, performed as part of the daily postoperative care, revealed a severely enlarged right ventricle with a decompressed left ventricle, implying the development of post-implant RHF. Bolus infusion of saline and reduction of pump flow (6.0 L/min to 3.0 L/min) led to normalization of both ventricular shapes in 30 s, suggesting that RHF could be managed without surgical interventions. Milrinone was started on POD six, followed by sildenafil administration on POD seven. Fluid balance was strictly adjusted under the close observation of daily echocardiograms. Milrinone and dobutamine were discontinued on PODs 18 and 21, respectively. The patient was listed for a heart transplant on POD 40. Despite reduced right ventricular function (right ventricular stroke work index of 182.34 mmHg*ml/m(− 2), body surface area 1.5 m(2)), she was successfully converted to implantable LVAD on POD 44 with no recurrence of post-implant RHF thereafter for four years. CONCLUSIONS: In post-implant RHF management, early detection, together with proper and prompt medical management, is crucial to avoiding any surgical intervention. Close observation of daily echocardiograms might be helpful in detecting subclinical RHF and is useful for post-implant medical management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-023-02368-1.
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spelling pubmed-105521932023-10-06 Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report Kunioka, Shingo Seguchi, Osamu Hada, Tasuku Mochizuki, Hiroki Shimojima, Masaya Watanabe, Takuya Tsukamoto, Yasumasa Tadokoro, Naoki Kainuma, Satoshi Fukushima, Satsuki Fujita, Tomoyuki Kamiya, Hiroyuki Fukushima, Norihide J Cardiothorac Surg Case Report BACKGROUND: Post-implant right heart failure (RHF) has been recognized as a crucial prognostic factor in patients receiving left ventricular assist devices (LVADs), and its management has long attracted attention from cardiologists and surgeons. CASE PRESENTATION: This report described an 18-year-old female with acutely deteriorating heart failure due to dilated cardiomyopathy who underwent paracorporeal pulsatile-flow LVAD and developed early post-implant RHF. At postoperative day (POD) six, she was almost asymptomatic at rest on 2.5 mg/kg/min of dobutamine; however, the echocardiogram, performed as part of the daily postoperative care, revealed a severely enlarged right ventricle with a decompressed left ventricle, implying the development of post-implant RHF. Bolus infusion of saline and reduction of pump flow (6.0 L/min to 3.0 L/min) led to normalization of both ventricular shapes in 30 s, suggesting that RHF could be managed without surgical interventions. Milrinone was started on POD six, followed by sildenafil administration on POD seven. Fluid balance was strictly adjusted under the close observation of daily echocardiograms. Milrinone and dobutamine were discontinued on PODs 18 and 21, respectively. The patient was listed for a heart transplant on POD 40. Despite reduced right ventricular function (right ventricular stroke work index of 182.34 mmHg*ml/m(− 2), body surface area 1.5 m(2)), she was successfully converted to implantable LVAD on POD 44 with no recurrence of post-implant RHF thereafter for four years. CONCLUSIONS: In post-implant RHF management, early detection, together with proper and prompt medical management, is crucial to avoiding any surgical intervention. Close observation of daily echocardiograms might be helpful in detecting subclinical RHF and is useful for post-implant medical management. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13019-023-02368-1. BioMed Central 2023-10-04 /pmc/articles/PMC10552193/ /pubmed/37794433 http://dx.doi.org/10.1186/s13019-023-02368-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Kunioka, Shingo
Seguchi, Osamu
Hada, Tasuku
Mochizuki, Hiroki
Shimojima, Masaya
Watanabe, Takuya
Tsukamoto, Yasumasa
Tadokoro, Naoki
Kainuma, Satoshi
Fukushima, Satsuki
Fujita, Tomoyuki
Kamiya, Hiroyuki
Fukushima, Norihide
Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title_full Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title_fullStr Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title_full_unstemmed Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title_short Successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
title_sort successful echocardiography-guided medical management of severe early post-implant right ventricular failure in a patient with left ventricular assist device support: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552193/
https://www.ncbi.nlm.nih.gov/pubmed/37794433
http://dx.doi.org/10.1186/s13019-023-02368-1
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