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MCProj: metacell projection for interpretable and quantitative use of transcriptional atlases
We describe MCProj—an algorithm for analyzing query scRNA-seq data by projections over reference single-cell atlases. We represent the reference as a manifold of annotated metacell gene expression distributions. We then interpret query metacells as mixtures of atlas distributions while correcting fo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552220/ https://www.ncbi.nlm.nih.gov/pubmed/37798781 http://dx.doi.org/10.1186/s13059-023-03069-7 |