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Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus
BACKGROUND: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 1059 T2...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552301/ https://www.ncbi.nlm.nih.gov/pubmed/37794445 http://dx.doi.org/10.1186/s13047-023-00663-7 |
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author | Chen, Weihao Wang, Xuedong Jiang, Qilin Wu, Jiyan Shi, Wanyan Wang, Xiaoxiao Yin, Yihu Zheng, Jiayin Hu, Xiang Lin, Cai Zhang, Xingxing |
author_facet | Chen, Weihao Wang, Xuedong Jiang, Qilin Wu, Jiyan Shi, Wanyan Wang, Xiaoxiao Yin, Yihu Zheng, Jiayin Hu, Xiang Lin, Cai Zhang, Xingxing |
author_sort | Chen, Weihao |
collection | PubMed |
description | BACKGROUND: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score < 3) and severe DFUs (Wagner grade score ≥ 3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results. RESULTS: Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017–1.865) (P = 0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079–2.103) (P = 0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD. CONCLUSIONS: Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders. |
format | Online Article Text |
id | pubmed-10552301 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105523012023-10-06 Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus Chen, Weihao Wang, Xuedong Jiang, Qilin Wu, Jiyan Shi, Wanyan Wang, Xiaoxiao Yin, Yihu Zheng, Jiayin Hu, Xiang Lin, Cai Zhang, Xingxing J Foot Ankle Res Research BACKGROUND: Triglyceride glucose (TyG) index is a good surrogate biomarker to evaluate insulin resistance (IR). The study aimed to investigate whether the TyG index is related to the severity of diabetic foot ulcers (DFUs) in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 1059 T2DM patients were enrolled in this observational, retrospective, single-center study. TyG index was calculated as ln[fasting triglycerides (mg/dl) × fasting glucose (mg/ dl)/2]. The severity of DFUs was classified into mild-to-moderate DFUs (Wagner grade score < 3) and severe DFUs (Wagner grade score ≥ 3) based on Wagner classification. Patients were stratified according to the tertiles of TyG index. Logistic regression models were implemented to explore the association between TyG index and the severity of DFUs. Subgroup analyses were used to verify the reliability of results. RESULTS: Compared with the reference lowest TyG tertile (T1), the highest tertile (T3) was associated with 0.377-fold increased risk of prevalence of severe DFUs (odds ratio [OR] 1.377, 95% confidence interval [CI] 1.017–1.865) (P = 0.039). After adjusting for potential confounders, the multivariable-adjusted OR and 95% CI were 1.506 (1.079–2.103) (P = 0.016) in patients with highest tertile. Moreover, subgroup analyses indicated that the association was stronger among men, patients with age ≥ 65 years, duration of diabetes more than 10 years, or without PAD. CONCLUSIONS: Elevated TyG index is independently associated with severity of DFUs even after adjusting conventional confounders. BioMed Central 2023-10-05 /pmc/articles/PMC10552301/ /pubmed/37794445 http://dx.doi.org/10.1186/s13047-023-00663-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Chen, Weihao Wang, Xuedong Jiang, Qilin Wu, Jiyan Shi, Wanyan Wang, Xiaoxiao Yin, Yihu Zheng, Jiayin Hu, Xiang Lin, Cai Zhang, Xingxing Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title | Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title_full | Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title_fullStr | Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title_full_unstemmed | Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title_short | Association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
title_sort | association between triglyceride glucose index and severity of diabetic foot ulcers in type 2 diabetes mellitus |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552301/ https://www.ncbi.nlm.nih.gov/pubmed/37794445 http://dx.doi.org/10.1186/s13047-023-00663-7 |
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