Large sample size and nonlinear sparse models outline epistatic effects in inflammatory bowel disease

BACKGROUND: Despite clear evidence of nonlinear interactions in the molecular architecture of polygenic diseases, linear models have so far appeared optimal in genotype-to-phenotype modeling. A key bottleneck for such modeling is that genetic data intrinsically suffers from underdetermination ([Form...

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Detalles Bibliográficos
Autores principales: Verplaetse, Nora, Passemiers, Antoine, Arany, Adam, Moreau, Yves, Raimondi, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552306/
https://www.ncbi.nlm.nih.gov/pubmed/37798735
http://dx.doi.org/10.1186/s13059-023-03064-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552306/
https://www.ncbi.nlm.nih.gov/pubmed/37798735
http://dx.doi.org/10.1186/s13059-023-03064-y

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