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Large sample size and nonlinear sparse models outline epistatic effects in inflammatory bowel disease
BACKGROUND: Despite clear evidence of nonlinear interactions in the molecular architecture of polygenic diseases, linear models have so far appeared optimal in genotype-to-phenotype modeling. A key bottleneck for such modeling is that genetic data intrinsically suffers from underdetermination ([Form...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552306/ https://www.ncbi.nlm.nih.gov/pubmed/37798735 http://dx.doi.org/10.1186/s13059-023-03064-y |