Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes

BACKGROUND: Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, there was conflicting evidence about the association between NFE2L2 mutation an...

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Detalles Bibliográficos
Autores principales: Wang, Kewei, Li, Zixi, Xuan, Ying, Zhao, Yong, Deng, Chao, Wang, Meidan, Xie, Chenjun, Yuan, Fenglai, Pang, Qingfeng, Mao, Wenjun, Cai, Dongyan, Zhong, Zhangfeng, Mei, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552358/
https://www.ncbi.nlm.nih.gov/pubmed/37794491
http://dx.doi.org/10.1186/s12935-023-03056-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552358/
https://www.ncbi.nlm.nih.gov/pubmed/37794491
http://dx.doi.org/10.1186/s12935-023-03056-9

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