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A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

BACKGROUND: Psoriasis is a chronic immune-mediated inflammatory systemic disease with skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques resulting from hyperproliferation of keratinocytes. Certolizumab pegol [CZP], a PEGylated antigen binding fragment of a humaniz...

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Detalles Bibliográficos
Autores principales:	Coto-Segura, Pablo, Segú-Vergés, Cristina, Martorell, Antonio, Moreno-Ramírez, David, Jorba, Guillem, Junet, Valentin, Guerri, Filippo, Daura, Xavier, Oliva, Baldomero, Cara, Carlos, Suárez-Magdalena, Olaya, Abraham, Sonya, Mas, José Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552644/ https://www.ncbi.nlm.nih.gov/pubmed/37809085 http://dx.doi.org/10.3389/fimmu.2023.1212981

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