Role of gasdermin family proteins in cancers (Review)

The gasdermin (GSDM) family comprises six proteins, including GSDMA-GSDME and Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular, GSDMD and GSDME are the most extensively studied proteins as the executioners of the pyroptosis process. Pyroptosis is a highly pr...

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Detalles Bibliográficos
Autores principales: Yang, Xin, Tang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552715/
https://www.ncbi.nlm.nih.gov/pubmed/37477150
http://dx.doi.org/10.3892/ijo.2023.5548
Descripción
Sumario:The gasdermin (GSDM) family comprises six proteins, including GSDMA-GSDME and Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular, GSDMD and GSDME are the most extensively studied proteins as the executioners of the pyroptosis process. Pyroptosis is a highly pro-inflammatory form of programmed cell death and is closely associated with the incidence, development and prognosis of multiple cancer types. The present review focused on the current knowledge of the molecular mechanism of GSDM-mediated pyroptosis, its intricate role in cancer and the potential therapeutic value of its anti-tumor effects.

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