Cargando…

Discovery medicine – the HVTN's iterative approach to developing an HIV-1 broadly neutralizing vaccine

PURPOSE OF REVIEW: In the past two decades, there has been an explosion in the discovery of HIV-1 broadly neutralizing antibodies (bnAbs) and associated vaccine strategies to induce them. This abundance of approaches necessitates a system that accurately and expeditiously identifies the most promisi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martin, Troy M., Robinson, Sam T., Huang, Yunda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2023
Materias:	IS AN HIV VACCINE STILL ACHIEVABLE?: Edited by Jim Kublin
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552837/ https://www.ncbi.nlm.nih.gov/pubmed/37712873 http://dx.doi.org/10.1097/COH.0000000000000821

Ejemplares similares

Progress with induction of HIV broadly neutralizing antibodies in the Duke Consortia for HIV/AIDS Vaccine Development
por: Haynes, Barton F., et al.
Publicado: (2023)

‘Immunization during ART and ATI for HIV-1 vaccine discovery/development’
por: Stamatatos, Leonidas
Publicado: (2023)

Accelerating HIV vaccine development through meaningful engagement of local scientists and communities
por: Chinyenze, Kundai, et al.
Publicado: (2023)

Generating and measuring effective vaccine-elicited HIV-specific CD8(+) T cell responses
por: Borgo, Gina M., et al.
Publicado: (2023)

Canakinumab for Treatment of Adult-Onset Still’s Disease to Achieve Reduction of Arthritic Manifestation (CONSIDER): phase II, randomised, double-blind, placebo-controlled, multicentre, investigator-initiated trial
por: Kedor, Claudia, et al.
Publicado: (2020)

Enhancing HIV-1 Neutralization by Increasing the Local Concentration of Membrane-Proximal External Region-Directed Broadly Neutralizing Antibodies
por: Kim, Soohyun, et al.
Publicado: (2022)

Divide and conquer: broadly neutralizing antibody combinations for improved HIV-1 viral coverage
por: Wagh, Kshitij, et al.
Publicado: (2023)

Broadly neutralizing antibody epitopes on HIV-1 particles are exposed after virus interaction with host cells
por: Rao, Priyanka Gadam, et al.
Publicado: (2023)

Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells
por: Cohen, Yehuda Z., et al.
Publicado: (2018)

Broadly Neutralizing Antibodies Display Potential for Prevention of HIV-1 Infection of Mucosal Tissue Superior to That of Nonneutralizing Antibodies
por: Cheeseman, Hannah M., et al.
Publicado: (2016)

Broadly Neutralizing Antibodies for HIV Eradication
por: Stephenson, Kathryn E., et al.
Publicado: (2016)

A calculated risk: Evaluating HIV resistance to the broadly neutralising antibodies10-1074 and 3BNC117
por: Zacharopoulou, Panagiota, et al.
Publicado: (2022)

2019 John M. Eisenberg Patient Safety and Quality Awards: An Interview with Gordon D. Schiff
por: Graber, Interviewed by Mark L.
Publicado: (2020)

Broad Sarbecovirus Neutralizing Antibodies Obtained by Computational Design and Synthetic Library Screening
por: Yang, Xuehua, et al.
Publicado: (2023)

A Derivative of the D5 Monoclonal Antibody That Targets the gp41 N-Heptad Repeat of HIV-1 with Broad Tier-2-Neutralizing Activity
por: Rubio, Adonis A., et al.
Publicado: (2021)

Optimization of the EC26-2A4 Epitope in the gp41 Membrane Proximal External Region Targeted by Neutralizing Antibodies from an Elite Controller
por: Ringel, Oliver, et al.
Publicado: (2018)

Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses
por: Beltran-Pavez, Carolina, et al.
Publicado: (2022)

Neutralizing Antibody Responses to Antigenically Drifted Influenza A(H3N2) Viruses among Children and Adolescents following 2014-2015 Inactivated and Live Attenuated Influenza Vaccination
por: Levine, Min Z., et al.
Publicado: (2016)

HIV and the eye
por: Gichuhi, Stephen, et al.
Publicado: (2020)

Characterization of T-Cell Responses to Conserved Regions of the HIV-1 Proteome in BALB/c Mice
por: Ondondo, Beatrice, et al.
Publicado: (2014)

Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa
por: Loxton, André G., et al.
Publicado: (2017)

Conformational Stability of the Hemagglutinin of H5N1 Influenza A Viruses Influences Susceptibility to Broadly Neutralizing Stem Antibodies
por: Wang, Wei, et al.
Publicado: (2018)

Prediction of serum HIV-1 neutralization titers of VRC01 in HIV-uninfected Antibody Mediated Prevention (AMP) trial participants
por: Huang, Yunda, et al.
Publicado: (2021)

Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus
por: Zhang, Yuting, et al.
Publicado: (2022)

Gut microbial diversity in HIV infection post combined antiretroviral therapy: a key target for prevention of cardiovascular disease
por: El-Far, Mohamed, et al.
Publicado: (2018)

Virus-Like Particles Containing the E2 Core Domain of Hepatitis C Virus Generate Broadly Neutralizing Antibodies in Guinea Pigs
por: McGregor, Joey, et al.
Publicado: (2022)

Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers
por: Schorcht, Anna, et al.
Publicado: (2020)

Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer
por: Zhan, Wuqiang, et al.
Publicado: (2022)

Mortality in HIV-infected patients with tuberculosis treated with streptomycin and a two-week intensified regimen: data from an HIV cohort study using inverse probability of treatment weighting
por: Alvarez-Uria, Gerardo, et al.
Publicado: (2016)

Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap
por: Gray, Glenda E., et al.
Publicado: (2016)

PRETERM BIRTH AND FETAL GROWTH RESTRICTION IN HIV-INFECTED BRAZILIAN PREGNANT WOMEN
por: dos REIS, Helena Lucia Barroso, et al.
Publicado: (2015)

DETERMINATION OF VIRAL TROPISM BY GENOTYPING AND PHENOTYPING ASSAYS IN BRAZILIAN HIV-1-INFECTED PATIENTS
por: Arruda, Liã Bárbara, et al.
Publicado: (2014)

Harm reduction interventions in HIV care: a qualitative exploration of patient and provider perspectives
por: Carlberg-Racich, Suzanne
Publicado: (2016)

Clusters of sub-Saharan African countries based on sociobehavioural characteristics and associated HIV incidence
por: Merzouki, Aziza, et al.
Publicado: (2021)

Effect of HSV-2 on population-level trends in HIV incidence in Uganda between 1990 and 2007
por: Biraro, Samuel, et al.
Publicado: (2013)

Cardiovascular risk evaluation and antiretroviral therapy effects in an HIV cohort: implications for clinical management: the CREATE 1 study
por: Aboud, M, et al.
Publicado: (2010)

A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model
por: Nakagawa, Fumiyo, et al.
Publicado: (2016)

Older adults at high risk of HIV infection in China: a systematic review and meta-analysis of observational studies
por: Wang, Yuan Yuan, et al.
Publicado: (2020)

Estimated blood pressure trajectories and hypertension patterns among pregnant women living with HIV, Haiti, 2007–2017
por: Tymejczyk, Olga, et al.
Publicado: (2022)

DISCORDANCE BETWEEN BODY MASS INDEX AND ANTHROPOMETRIC MEASUREMENTS AMONG HIV-1-INFECTED PATIENTS ON ANTIRETROVIRAL THERAPY AND WITH LIPOATROPHY/LIPOHYPERTROPHY SYNDROME
por: SOARES, Lismeia Raimundo, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_gnt7ikd4hkemp3h08t0j1oapuk