Cargando…

The ToxCast pipeline: updates to curve-fitting approaches and database structure

Introduction: The US Environmental Protection Agency Toxicity Forecaster (ToxCast) program makes in vitro medium- and high-throughput screening assay data publicly available for prioritization and hazard characterization of thousands of chemicals. The assays employ a variety of technologies to evalu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feshuk, M., Kolaczkowski, L., Dunham, K., Davidson-Fritz, S. E., Carstens, K. E., Brown, J., Judson, R. S., Paul Friedman, K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552852/ https://www.ncbi.nlm.nih.gov/pubmed/37808181 http://dx.doi.org/10.3389/ftox.2023.1275980

Ejemplares similares

ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database
por: Feshuk, Madison, et al.
Publicado: (2023)

Uncertainty quantification in ToxCast high throughput screening
por: Watt, Eric D., et al.
Publicado: (2018)

Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters
por: Onyango, David O, et al.
Publicado: (2023)

Comment on “On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens”
por: Houck, Keith A., et al.
Publicado: (2017)

On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens
por: Janesick, Amanda Shaine, et al.
Publicado: (2016)

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
por: Reif, David M., et al.
Publicado: (2010)

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
por: Judson, Richard S., et al.
Publicado: (2010)

Potential of ToxCast Data in the Safety Assessment of Food Chemicals
por: Punt, Ans, et al.
Publicado: (2020)

Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database
por: Kortagere, Sandhya, et al.
Publicado: (2010)

Reply to “Comment on ‘On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens’”
por: Janesick, Amanda S., et al.
Publicado: (2017)

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays
por: Sipes, Nisha S., et al.
Publicado: (2013)

QSAR modeling for In vitro assays: linking ToxCast™ database to the integrated modeling framework “OCHEM”
por: Abdelaziz, Ahmed, et al.
Publicado: (2012)

ToxCast(™) Wants You: Recommendations for Engaging the Broader Scientific Community
por: Arnold, Carrie
Publicado: (2015)

ToxCast EPA in Vitro to in Vivo Challenge: Insight into the Rank-I Model
por: Novotarskyi, Sergii, et al.
Publicado: (2016)

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure
por: Shah, Imran, et al.
Publicado: (2015)

ToxCast on Target: In Vitro Assays and Computer Modeling Show Promise for Screening Chemicals
por: Haynes, Rebecca Clay
Publicado: (2010)

Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential
por: Gangwal, Sumit, et al.
Publicado: (2011)

Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food
por: Naidenko, Olga V., et al.
Publicado: (2021)

On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals
por: Filer, Dayne L., et al.
Publicado: (2022)

ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation
por: Wolter, Justin M., et al.
Publicado: (2022)

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data
por: Auerbach, Scott, et al.
Publicado: (2016)

Evaluation of OASIS QSAR Models Using ToxCast™ in Vitro Estrogen and Androgen Receptor Binding Data and Application in an Integrated Endocrine Screening Approach
por: Bhhatarai, Barun, et al.
Publicado: (2016)

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits
por: Boyd, Windy A., et al.
Publicado: (2015)

In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox
por: Chushak, Y. G., et al.
Publicado: (2018)

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis
por: Foley, Briana, et al.
Publicado: (2017)

Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis
por: Combs, Parker, et al.
Publicado: (2023)

Corrigendum: Tox21Enricher-Shiny: an R Shiny application for toxicity functional annotation analysis
por: Combs, Parker, et al.
Publicado: (2023)

Screening ToxCast™ for Chemicals That Affect Cholesterol Biosynthesis: Studies in Cell Culture and Human Induced Pluripotent Stem Cell–Derived Neuroprogenitors
por: Wages, Phillip A., et al.
Publicado: (2020)

Analysis of structure–activity and structure–mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging the ToxCast library
por: Sahoo, Ajaya Kumar, et al.
Publicado: (2023)

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition
por: Wang, Jun, et al.
Publicado: (2019)

Using Live Imaging and FUCCI Embryonic Stem Cells to Rank DevTox Risks: Adverse Growth Effects of PFOA Compared With DEP Are 26 Times Faster, 1,000 Times More Sensitive, and 13 Times Greater in Magnitude
por: Abdulhasan, Mohammed, et al.
Publicado: (2021)

Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment
por: Jaklin, Manuela, et al.
Publicado: (2022)

Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
por: Loizou, George, et al.
Publicado: (2022)

Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration–Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
por: Loizou, George, et al.
Publicado: (2021)

Development of the InTelligence And Machine LEarning (TAME) Toolkit for Introductory Data Science, Chemical-Biological Analyses, Predictive Modeling, and Database Mining for Environmental Health Research
por: Roell, Kyle, et al.
Publicado: (2022)

Development of a New Threshold of Toxicological Concern Database of Non-cancer Toxicity Endpoints for Industrial Chemicals
por: Yamada, Takashi, et al.
Publicado: (2021)

Use of the online poisons information database TOXBASE and admissions rates for poisoned patients from emergency departments in England and Wales during 2008 to 2015
por: Pyper, Kate, et al.
Publicado: (2020)

Using the Isolated Rat Placenta to Assess Fetoplacental Hemodynamics
por: Garner, K. L., et al.
Publicado: (2022)

From vision toward best practices: Evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow
por: Reardon, Anthony J. F., et al.
Publicado: (2023)

Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework
por: Sammi, Shreesh Raj, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_g0q7ff74b8p0j2qj7610glecpm