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Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department

Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the cli...

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Autores principales: Dev, Anand, Kumar, Abhay, Kumar, Santosh, Gunjan, Gagan, Singh, Siddharth, Arun, Nitali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552881/
https://www.ncbi.nlm.nih.gov/pubmed/37809143
http://dx.doi.org/10.7759/cureus.44719
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author Dev, Anand
Kumar, Abhay
Kumar, Santosh
Gunjan, Gagan
Singh, Siddharth
Arun, Nitali
author_facet Dev, Anand
Kumar, Abhay
Kumar, Santosh
Gunjan, Gagan
Singh, Siddharth
Arun, Nitali
author_sort Dev, Anand
collection PubMed
description Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in the Emergency Department of Indira Gandhi Institute of Medical Sciences, Patna. It investigates factors associated with patient outcomes and compares platelet transfusion requirements among different etiological groups. Methods: In this cross-sectional observational study, 350 patients with acute undifferentiated fever with thrombocytopenia were analyzed for one year from October '21 to September '22. Pre-existing chronic infectious diseases, liver cirrhosis, and autoimmune conditions were excluded. Results: Thrombocytopenia was observed in all patients, with 65% having platelet counts below 50,000/µL. Associations were found between the degree of thrombocytopenia and organ dysfunction, shock, and third space loss. Logistic regression analysis identified thrombocytopenia, organ dysfunction, and platelet transfusion requirement as significant predictors of the overall outcome. Etiological group comparisons revealed higher platelet transfusion requirements in the bacterial group. Conclusion: Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based on etiological factors are crucial. Further research should focus on specific viral aetiologies in acute undifferentiated fever with thrombocytopenia.
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spelling pubmed-105528812023-10-06 Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department Dev, Anand Kumar, Abhay Kumar, Santosh Gunjan, Gagan Singh, Siddharth Arun, Nitali Cureus Emergency Medicine Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in the Emergency Department of Indira Gandhi Institute of Medical Sciences, Patna. It investigates factors associated with patient outcomes and compares platelet transfusion requirements among different etiological groups. Methods: In this cross-sectional observational study, 350 patients with acute undifferentiated fever with thrombocytopenia were analyzed for one year from October '21 to September '22. Pre-existing chronic infectious diseases, liver cirrhosis, and autoimmune conditions were excluded. Results: Thrombocytopenia was observed in all patients, with 65% having platelet counts below 50,000/µL. Associations were found between the degree of thrombocytopenia and organ dysfunction, shock, and third space loss. Logistic regression analysis identified thrombocytopenia, organ dysfunction, and platelet transfusion requirement as significant predictors of the overall outcome. Etiological group comparisons revealed higher platelet transfusion requirements in the bacterial group. Conclusion: Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based on etiological factors are crucial. Further research should focus on specific viral aetiologies in acute undifferentiated fever with thrombocytopenia. Cureus 2023-09-05 /pmc/articles/PMC10552881/ /pubmed/37809143 http://dx.doi.org/10.7759/cureus.44719 Text en Copyright © 2023, Dev et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Emergency Medicine
Dev, Anand
Kumar, Abhay
Kumar, Santosh
Gunjan, Gagan
Singh, Siddharth
Arun, Nitali
Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title_full Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title_fullStr Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title_full_unstemmed Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title_short Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
title_sort clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in an emergency department
topic Emergency Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552881/
https://www.ncbi.nlm.nih.gov/pubmed/37809143
http://dx.doi.org/10.7759/cureus.44719
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