Cargando…
Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department
Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the cli...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552881/ https://www.ncbi.nlm.nih.gov/pubmed/37809143 http://dx.doi.org/10.7759/cureus.44719 |
_version_ | 1785116050155634688 |
---|---|
author | Dev, Anand Kumar, Abhay Kumar, Santosh Gunjan, Gagan Singh, Siddharth Arun, Nitali |
author_facet | Dev, Anand Kumar, Abhay Kumar, Santosh Gunjan, Gagan Singh, Siddharth Arun, Nitali |
author_sort | Dev, Anand |
collection | PubMed |
description | Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in the Emergency Department of Indira Gandhi Institute of Medical Sciences, Patna. It investigates factors associated with patient outcomes and compares platelet transfusion requirements among different etiological groups. Methods: In this cross-sectional observational study, 350 patients with acute undifferentiated fever with thrombocytopenia were analyzed for one year from October '21 to September '22. Pre-existing chronic infectious diseases, liver cirrhosis, and autoimmune conditions were excluded. Results: Thrombocytopenia was observed in all patients, with 65% having platelet counts below 50,000/µL. Associations were found between the degree of thrombocytopenia and organ dysfunction, shock, and third space loss. Logistic regression analysis identified thrombocytopenia, organ dysfunction, and platelet transfusion requirement as significant predictors of the overall outcome. Etiological group comparisons revealed higher platelet transfusion requirements in the bacterial group. Conclusion: Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based on etiological factors are crucial. Further research should focus on specific viral aetiologies in acute undifferentiated fever with thrombocytopenia. |
format | Online Article Text |
id | pubmed-10552881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105528812023-10-06 Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department Dev, Anand Kumar, Abhay Kumar, Santosh Gunjan, Gagan Singh, Siddharth Arun, Nitali Cureus Emergency Medicine Introduction: Acute undifferentiated fever with thrombocytopenia is a common and challenging clinical presentation encountered in the emergency departments of tertiary care centers, particularly in tropical regions, often requiring prompt evaluation and management. The study aimed to explore the clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in the Emergency Department of Indira Gandhi Institute of Medical Sciences, Patna. It investigates factors associated with patient outcomes and compares platelet transfusion requirements among different etiological groups. Methods: In this cross-sectional observational study, 350 patients with acute undifferentiated fever with thrombocytopenia were analyzed for one year from October '21 to September '22. Pre-existing chronic infectious diseases, liver cirrhosis, and autoimmune conditions were excluded. Results: Thrombocytopenia was observed in all patients, with 65% having platelet counts below 50,000/µL. Associations were found between the degree of thrombocytopenia and organ dysfunction, shock, and third space loss. Logistic regression analysis identified thrombocytopenia, organ dysfunction, and platelet transfusion requirement as significant predictors of the overall outcome. Etiological group comparisons revealed higher platelet transfusion requirements in the bacterial group. Conclusion: Prompt recognition and management of thrombocytopenia in acute undifferentiated fever are vital. Thrombocytopenia, along with organ dysfunction and shock, significantly influence patient outcomes. Tailored interventions based on etiological factors are crucial. Further research should focus on specific viral aetiologies in acute undifferentiated fever with thrombocytopenia. Cureus 2023-09-05 /pmc/articles/PMC10552881/ /pubmed/37809143 http://dx.doi.org/10.7759/cureus.44719 Text en Copyright © 2023, Dev et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Emergency Medicine Dev, Anand Kumar, Abhay Kumar, Santosh Gunjan, Gagan Singh, Siddharth Arun, Nitali Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title | Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title_full | Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title_fullStr | Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title_full_unstemmed | Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title_short | Clinical and Etiological Profile of Acute Undifferentiated Fever With Thrombocytopenia in an Emergency Department |
title_sort | clinical and etiological profile of acute undifferentiated fever with thrombocytopenia in an emergency department |
topic | Emergency Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552881/ https://www.ncbi.nlm.nih.gov/pubmed/37809143 http://dx.doi.org/10.7759/cureus.44719 |
work_keys_str_mv | AT devanand clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment AT kumarabhay clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment AT kumarsantosh clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment AT gunjangagan clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment AT singhsiddharth clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment AT arunnitali clinicalandetiologicalprofileofacuteundifferentiatedfeverwiththrombocytopeniainanemergencydepartment |