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Clinical strategies for securing negative proximal margin in early gastric cancer
Securing an appropriate proximal resection margin (PRM) is crucial for oncological safety in treating gastric cancer. This study investigated the clinicopathological characteristics of patients with incomplete PRM length of <2 cm in early gastric cancer. Clinicopathological data of 1,493 patients...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552986/ https://www.ncbi.nlm.nih.gov/pubmed/37800787 http://dx.doi.org/10.1097/MD.0000000000035393 |
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author | Chung, Jae Hun Im, Dong Won Ryu, Dae-Gon Choi, Cheol Woong Kim, Su Jin Hwang, Sun-Hwi Lee, Si-Hak |
author_facet | Chung, Jae Hun Im, Dong Won Ryu, Dae-Gon Choi, Cheol Woong Kim, Su Jin Hwang, Sun-Hwi Lee, Si-Hak |
author_sort | Chung, Jae Hun |
collection | PubMed |
description | Securing an appropriate proximal resection margin (PRM) is crucial for oncological safety in treating gastric cancer. This study investigated the clinicopathological characteristics of patients with incomplete PRM length of <2 cm in early gastric cancer. Clinicopathological data of 1,493 patients who underwent subtotal gastrectomy for early gastric cancer in 2012 to 2021 were retrospectively reviewed. Patients were divided into the PRM length of <2 cm and ≥2 cm groups based on pathological results. Univariate and multivariate analyses evaluated factors for incomplete PRM length. Factors related to patients with a relative PRM positive were also analyzed. The proportion of patients with a PRM length of <2 cm was 17.9% (267/1,493). Multivariate regression analysis revealed that age <50, preoperative endoscopic size of ≥3 cm, size discrepancy of ≥2 cm, and midbody tumor with a lesser curvature significantly contributed to the PRM length of <2 cm. Twenty-four patients had a relative PRM positive (24/1493, 1.6%). An incomplete PRM was the only risk factor for a positive relative PRM. Surgical treatment for early gastric cancer requires an accurate preoperative endoscopic tumor size and location evaluation. A more aggressive resection is recommended for patients with age <50, preoperative endoscopic size of ≥3 cm, size discrepancy of ≥2 cm, and midbody tumor with a lesser curvature. |
format | Online Article Text |
id | pubmed-10552986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105529862023-10-06 Clinical strategies for securing negative proximal margin in early gastric cancer Chung, Jae Hun Im, Dong Won Ryu, Dae-Gon Choi, Cheol Woong Kim, Su Jin Hwang, Sun-Hwi Lee, Si-Hak Medicine (Baltimore) 7100 Securing an appropriate proximal resection margin (PRM) is crucial for oncological safety in treating gastric cancer. This study investigated the clinicopathological characteristics of patients with incomplete PRM length of <2 cm in early gastric cancer. Clinicopathological data of 1,493 patients who underwent subtotal gastrectomy for early gastric cancer in 2012 to 2021 were retrospectively reviewed. Patients were divided into the PRM length of <2 cm and ≥2 cm groups based on pathological results. Univariate and multivariate analyses evaluated factors for incomplete PRM length. Factors related to patients with a relative PRM positive were also analyzed. The proportion of patients with a PRM length of <2 cm was 17.9% (267/1,493). Multivariate regression analysis revealed that age <50, preoperative endoscopic size of ≥3 cm, size discrepancy of ≥2 cm, and midbody tumor with a lesser curvature significantly contributed to the PRM length of <2 cm. Twenty-four patients had a relative PRM positive (24/1493, 1.6%). An incomplete PRM was the only risk factor for a positive relative PRM. Surgical treatment for early gastric cancer requires an accurate preoperative endoscopic tumor size and location evaluation. A more aggressive resection is recommended for patients with age <50, preoperative endoscopic size of ≥3 cm, size discrepancy of ≥2 cm, and midbody tumor with a lesser curvature. Lippincott Williams & Wilkins 2023-10-06 /pmc/articles/PMC10552986/ /pubmed/37800787 http://dx.doi.org/10.1097/MD.0000000000035393 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 7100 Chung, Jae Hun Im, Dong Won Ryu, Dae-Gon Choi, Cheol Woong Kim, Su Jin Hwang, Sun-Hwi Lee, Si-Hak Clinical strategies for securing negative proximal margin in early gastric cancer |
title | Clinical strategies for securing negative proximal margin in early gastric cancer |
title_full | Clinical strategies for securing negative proximal margin in early gastric cancer |
title_fullStr | Clinical strategies for securing negative proximal margin in early gastric cancer |
title_full_unstemmed | Clinical strategies for securing negative proximal margin in early gastric cancer |
title_short | Clinical strategies for securing negative proximal margin in early gastric cancer |
title_sort | clinical strategies for securing negative proximal margin in early gastric cancer |
topic | 7100 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552986/ https://www.ncbi.nlm.nih.gov/pubmed/37800787 http://dx.doi.org/10.1097/MD.0000000000035393 |
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