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FZD7: A potential biomarker for endometriosis
BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. M...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553041/ https://www.ncbi.nlm.nih.gov/pubmed/37800830 http://dx.doi.org/10.1097/MD.0000000000035406 |
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author | Lan, Suwei Zhang, Zhengmao Li, Qing |
author_facet | Lan, Suwei Zhang, Zhengmao Li, Qing |
author_sort | Lan, Suwei |
collection | PubMed |
description | BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. METHODS: In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7. RESULTS: These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis. CONCLUSION: FZD7 may serve as a potential therapeutic target for endometriosis treatment. |
format | Online Article Text |
id | pubmed-10553041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105530412023-10-06 FZD7: A potential biomarker for endometriosis Lan, Suwei Zhang, Zhengmao Li, Qing Medicine (Baltimore) 3700 BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. METHODS: In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7. RESULTS: These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis. CONCLUSION: FZD7 may serve as a potential therapeutic target for endometriosis treatment. Lippincott Williams & Wilkins 2023-10-06 /pmc/articles/PMC10553041/ /pubmed/37800830 http://dx.doi.org/10.1097/MD.0000000000035406 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 3700 Lan, Suwei Zhang, Zhengmao Li, Qing FZD7: A potential biomarker for endometriosis |
title | FZD7: A potential biomarker for endometriosis |
title_full | FZD7: A potential biomarker for endometriosis |
title_fullStr | FZD7: A potential biomarker for endometriosis |
title_full_unstemmed | FZD7: A potential biomarker for endometriosis |
title_short | FZD7: A potential biomarker for endometriosis |
title_sort | fzd7: a potential biomarker for endometriosis |
topic | 3700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553041/ https://www.ncbi.nlm.nih.gov/pubmed/37800830 http://dx.doi.org/10.1097/MD.0000000000035406 |
work_keys_str_mv | AT lansuwei fzd7apotentialbiomarkerforendometriosis AT zhangzhengmao fzd7apotentialbiomarkerforendometriosis AT liqing fzd7apotentialbiomarkerforendometriosis |