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FZD7: A potential biomarker for endometriosis

BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. M...

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Detalles Bibliográficos
Autores principales: Lan, Suwei, Zhang, Zhengmao, Li, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553041/
https://www.ncbi.nlm.nih.gov/pubmed/37800830
http://dx.doi.org/10.1097/MD.0000000000035406
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author Lan, Suwei
Zhang, Zhengmao
Li, Qing
author_facet Lan, Suwei
Zhang, Zhengmao
Li, Qing
author_sort Lan, Suwei
collection PubMed
description BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. METHODS: In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7. RESULTS: These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis. CONCLUSION: FZD7 may serve as a potential therapeutic target for endometriosis treatment.
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spelling pubmed-105530412023-10-06 FZD7: A potential biomarker for endometriosis Lan, Suwei Zhang, Zhengmao Li, Qing Medicine (Baltimore) 3700 BACKGROUND: Endometriosis is a chronic inflammatory, benign disorder that often co-occurs with adenomyosis and/or leiomyoma. The overall incidence of endometriosis in reproductive period women was nearly 10%. However, the exact mechanisms of endometriosis-associated pathogenesis are still unknown. METHODS: In this study, we aimed to investigate whether Frizzled-7 (FZD7) would effectively promote the development of endometriosis. The microarray-based data analysis was performed to screen endometriosis-related differentially expressed genes. This process uncovered specific hub genes, and the nexus of vital genes and ferroptosis-related genes were pinpointed. Then, we collected human endometrial and endometriotic tissues from patients with endometriosis of the ovary (n = 39) and control patients without endometriosis (n = 10, who underwent hysterectomy for uterine fibroids) to compare the expression of FZD7. RESULTS: These findings indicated that the expression of FZD7 was high compared with normal endometrium, and FZD7 may promote the progression of endometriosis. CONCLUSION: FZD7 may serve as a potential therapeutic target for endometriosis treatment. Lippincott Williams & Wilkins 2023-10-06 /pmc/articles/PMC10553041/ /pubmed/37800830 http://dx.doi.org/10.1097/MD.0000000000035406 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 3700
Lan, Suwei
Zhang, Zhengmao
Li, Qing
FZD7: A potential biomarker for endometriosis
title FZD7: A potential biomarker for endometriosis
title_full FZD7: A potential biomarker for endometriosis
title_fullStr FZD7: A potential biomarker for endometriosis
title_full_unstemmed FZD7: A potential biomarker for endometriosis
title_short FZD7: A potential biomarker for endometriosis
title_sort fzd7: a potential biomarker for endometriosis
topic 3700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553041/
https://www.ncbi.nlm.nih.gov/pubmed/37800830
http://dx.doi.org/10.1097/MD.0000000000035406
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