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A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges
Behcet’s disease (BD) is a chronic inflammatory disorder characterized by a relapsing and remitting course and multisystem involvement. The authors present a case report of a 20-year-old male who presented with bilateral knee joint pain, oral and genital ulcers, and papulopustular skin lesions. The...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553148/ https://www.ncbi.nlm.nih.gov/pubmed/37811046 http://dx.doi.org/10.1097/MS9.0000000000001279 |
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author | Mahaju, Satyam Achhami, Eliz Lamichhane, Seshkanta Chalise, Khem N. Gautam, Rabin |
author_facet | Mahaju, Satyam Achhami, Eliz Lamichhane, Seshkanta Chalise, Khem N. Gautam, Rabin |
author_sort | Mahaju, Satyam |
collection | PubMed |
description | Behcet’s disease (BD) is a chronic inflammatory disorder characterized by a relapsing and remitting course and multisystem involvement. The authors present a case report of a 20-year-old male who presented with bilateral knee joint pain, oral and genital ulcers, and papulopustular skin lesions. The patient’s clinical history, physical examination, laboratory findings, and biopsy results were consistent with the diagnosis of BD. The patient tested positive for the HLA-B51 allele, confirming a genetic predisposition. The diagnosis was supported by a positive pathergy test and a skin biopsy showing vasculitis. The diagnostic criteria established by the international study group and the International Criteria for Behcet’s Disease were fulfilled. Treatment consisted of colchicine, azathioprine, and topical corticosteroids. This case highlights the importance of recognizing the varied clinical presentations of BD and the need for a multidisciplinary approach to diagnosis and management. Early and accurate diagnosis is crucial to prevent severe complications and improve patient outcomes. |
format | Online Article Text |
id | pubmed-10553148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-105531482023-10-06 A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges Mahaju, Satyam Achhami, Eliz Lamichhane, Seshkanta Chalise, Khem N. Gautam, Rabin Ann Med Surg (Lond) Case Reports Behcet’s disease (BD) is a chronic inflammatory disorder characterized by a relapsing and remitting course and multisystem involvement. The authors present a case report of a 20-year-old male who presented with bilateral knee joint pain, oral and genital ulcers, and papulopustular skin lesions. The patient’s clinical history, physical examination, laboratory findings, and biopsy results were consistent with the diagnosis of BD. The patient tested positive for the HLA-B51 allele, confirming a genetic predisposition. The diagnosis was supported by a positive pathergy test and a skin biopsy showing vasculitis. The diagnostic criteria established by the international study group and the International Criteria for Behcet’s Disease were fulfilled. Treatment consisted of colchicine, azathioprine, and topical corticosteroids. This case highlights the importance of recognizing the varied clinical presentations of BD and the need for a multidisciplinary approach to diagnosis and management. Early and accurate diagnosis is crucial to prevent severe complications and improve patient outcomes. Lippincott Williams & Wilkins 2023-09-05 /pmc/articles/PMC10553148/ /pubmed/37811046 http://dx.doi.org/10.1097/MS9.0000000000001279 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Case Reports Mahaju, Satyam Achhami, Eliz Lamichhane, Seshkanta Chalise, Khem N. Gautam, Rabin A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title | A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title_full | A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title_fullStr | A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title_full_unstemmed | A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title_short | A rare case of Behcet’s disease in Nepal: multisystem manifestations and diagnostic challenges |
title_sort | rare case of behcet’s disease in nepal: multisystem manifestations and diagnostic challenges |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553148/ https://www.ncbi.nlm.nih.gov/pubmed/37811046 http://dx.doi.org/10.1097/MS9.0000000000001279 |
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