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Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria
Healthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553227/ https://www.ncbi.nlm.nih.gov/pubmed/37796780 http://dx.doi.org/10.1371/journal.pone.0292440 |
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author | Ige, Fehintola Anthonia Ohihoin, Gregory Aigbe Osuolale, Kazeem Dada, Adedamola Onyia, Ngozi Johnson, Adeyemi Okwuraiwe, Azuka Patrick Odediran, Omoladun Liboro, Gideon Aniedobe, Maureen Mogaji, Sunday Nwaiwu, Stephanie Ogechi Akande, Ibukun Ruth Audu, Rosemary Ajuma Salako, Babatunde Lawal |
author_facet | Ige, Fehintola Anthonia Ohihoin, Gregory Aigbe Osuolale, Kazeem Dada, Adedamola Onyia, Ngozi Johnson, Adeyemi Okwuraiwe, Azuka Patrick Odediran, Omoladun Liboro, Gideon Aniedobe, Maureen Mogaji, Sunday Nwaiwu, Stephanie Ogechi Akande, Ibukun Ruth Audu, Rosemary Ajuma Salako, Babatunde Lawal |
author_sort | Ige, Fehintola Anthonia |
collection | PubMed |
description | Healthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos Nigeria to determine the prevalence of IgG antibodies (seroprevalence) and SARS-CoV-2 active infection rate via a positive rtPCR result, the cross-sectional study was conducted between December 2020 and July 2021. Nasopharyngeal and blood samples were collected from HCWs and screened for SARS-CoV-2 infection using the rtPCR technique and antibody using the Abbott anti-SARS-CoV-2 IgG CMIA assay, respectively. Demographic and occupational exposures data were obtained and analysed using descriptive and inferential statistics, variables significant via inferential statistics were subjected to a multivariate analysis. A total of 413 participants were enrolled, with a mean age in years of 38.4±11.0. The seroprevalence was 30.9% (115/372) while 63/395 (15.9%) were actively infected with the virus. HCWs whose job role had direct contact with patients had a higher percentage of SARS-CoV-2 infection when compared with those not in direct contact, also being a health care worker was significantly associated with getting a positive COVID-19 PCR result. In conclusion the SARS-CoV-2 seroprevalence seen in this study was higher than national serosurvey estimates indicating HCWs are at higher risk of COVID-19 infection when compared to the general public. Vaccination and effective implementation of infection control measures are important to protect HCWs. |
format | Online Article Text |
id | pubmed-10553227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105532272023-10-06 Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria Ige, Fehintola Anthonia Ohihoin, Gregory Aigbe Osuolale, Kazeem Dada, Adedamola Onyia, Ngozi Johnson, Adeyemi Okwuraiwe, Azuka Patrick Odediran, Omoladun Liboro, Gideon Aniedobe, Maureen Mogaji, Sunday Nwaiwu, Stephanie Ogechi Akande, Ibukun Ruth Audu, Rosemary Ajuma Salako, Babatunde Lawal PLoS One Research Article Healthcare workers (HCWs) are disproportionately infected with SARS-CoV-2 when compared to members of the general public; estimating the seroprevalence of SARS-CoV-2 antibody and SARS-CoV-2 infection rate among HCWs is therefore crucial. This study was carried out in four health facilities in Lagos Nigeria to determine the prevalence of IgG antibodies (seroprevalence) and SARS-CoV-2 active infection rate via a positive rtPCR result, the cross-sectional study was conducted between December 2020 and July 2021. Nasopharyngeal and blood samples were collected from HCWs and screened for SARS-CoV-2 infection using the rtPCR technique and antibody using the Abbott anti-SARS-CoV-2 IgG CMIA assay, respectively. Demographic and occupational exposures data were obtained and analysed using descriptive and inferential statistics, variables significant via inferential statistics were subjected to a multivariate analysis. A total of 413 participants were enrolled, with a mean age in years of 38.4±11.0. The seroprevalence was 30.9% (115/372) while 63/395 (15.9%) were actively infected with the virus. HCWs whose job role had direct contact with patients had a higher percentage of SARS-CoV-2 infection when compared with those not in direct contact, also being a health care worker was significantly associated with getting a positive COVID-19 PCR result. In conclusion the SARS-CoV-2 seroprevalence seen in this study was higher than national serosurvey estimates indicating HCWs are at higher risk of COVID-19 infection when compared to the general public. Vaccination and effective implementation of infection control measures are important to protect HCWs. Public Library of Science 2023-10-05 /pmc/articles/PMC10553227/ /pubmed/37796780 http://dx.doi.org/10.1371/journal.pone.0292440 Text en © 2023 Ige et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ige, Fehintola Anthonia Ohihoin, Gregory Aigbe Osuolale, Kazeem Dada, Adedamola Onyia, Ngozi Johnson, Adeyemi Okwuraiwe, Azuka Patrick Odediran, Omoladun Liboro, Gideon Aniedobe, Maureen Mogaji, Sunday Nwaiwu, Stephanie Ogechi Akande, Ibukun Ruth Audu, Rosemary Ajuma Salako, Babatunde Lawal Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title | Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title_full | Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title_fullStr | Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title_full_unstemmed | Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title_short | Seroprevalence of SARS-CoV-2 IgG among healthcare workers in Lagos, Nigeria |
title_sort | seroprevalence of sars-cov-2 igg among healthcare workers in lagos, nigeria |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553227/ https://www.ncbi.nlm.nih.gov/pubmed/37796780 http://dx.doi.org/10.1371/journal.pone.0292440 |
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