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Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease

Clinical rating scales typically includes subjective evaluations, and their time-limited duration may fail to capture daily fluctuations in motor symptoms resulting from Parkinson’s disease (PD). Recently, a new tool (i.e. the PD-Watch) has been proposed for the objective and continuous assessment o...

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Autores principales: Battista, Luigi, Casali, Miriam, Brusa, Livia, Radicati, Fabiana Giada, Stocchi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553324/
https://www.ncbi.nlm.nih.gov/pubmed/37796842
http://dx.doi.org/10.1371/journal.pone.0287139
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author Battista, Luigi
Casali, Miriam
Brusa, Livia
Radicati, Fabiana Giada
Stocchi, Fabrizio
author_facet Battista, Luigi
Casali, Miriam
Brusa, Livia
Radicati, Fabiana Giada
Stocchi, Fabrizio
author_sort Battista, Luigi
collection PubMed
description Clinical rating scales typically includes subjective evaluations, and their time-limited duration may fail to capture daily fluctuations in motor symptoms resulting from Parkinson’s disease (PD). Recently, a new tool (i.e. the PD-Watch) has been proposed for the objective and continuous assessment of PD motor manifestations based on evaluating frequency data from a wrist-worn tri-axial accelerometer and identifying specific movement patterns typically associated with disorders. This reduces the probability of confusing physiological or pathological movements occurring at the same frequency. In this work, we present a new method for assessing motor fluctuations through a wrist-worn accelerometer. We also explore the agreement between the continuous data generated by the proposed method and data reported in the patient diaries. In this study, twelve PD patients were recruited with an overall recording duration of 528 hours. Results of this preliminary study show that the proposed tool has suitable and adequate performances for analysing the motor signs of PD patients, and the estimated sensitivity, specificity, and accuracy of the tool are 85%, 94%, and 91%, respectively.
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spelling pubmed-105533242023-10-06 Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease Battista, Luigi Casali, Miriam Brusa, Livia Radicati, Fabiana Giada Stocchi, Fabrizio PLoS One Research Article Clinical rating scales typically includes subjective evaluations, and their time-limited duration may fail to capture daily fluctuations in motor symptoms resulting from Parkinson’s disease (PD). Recently, a new tool (i.e. the PD-Watch) has been proposed for the objective and continuous assessment of PD motor manifestations based on evaluating frequency data from a wrist-worn tri-axial accelerometer and identifying specific movement patterns typically associated with disorders. This reduces the probability of confusing physiological or pathological movements occurring at the same frequency. In this work, we present a new method for assessing motor fluctuations through a wrist-worn accelerometer. We also explore the agreement between the continuous data generated by the proposed method and data reported in the patient diaries. In this study, twelve PD patients were recruited with an overall recording duration of 528 hours. Results of this preliminary study show that the proposed tool has suitable and adequate performances for analysing the motor signs of PD patients, and the estimated sensitivity, specificity, and accuracy of the tool are 85%, 94%, and 91%, respectively. Public Library of Science 2023-10-05 /pmc/articles/PMC10553324/ /pubmed/37796842 http://dx.doi.org/10.1371/journal.pone.0287139 Text en © 2023 Battista et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Battista, Luigi
Casali, Miriam
Brusa, Livia
Radicati, Fabiana Giada
Stocchi, Fabrizio
Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title_full Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title_fullStr Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title_full_unstemmed Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title_short Clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and ON/OFF states in patients with Parkinson’s disease
title_sort clinical assessment of a new wearable tool for continuous and objective recording of motor fluctuations and on/off states in patients with parkinson’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553324/
https://www.ncbi.nlm.nih.gov/pubmed/37796842
http://dx.doi.org/10.1371/journal.pone.0287139
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