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Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study

BACKGROUND: Forced vital capacity (FVC) and six-minute walk distance (6MWD) are robust markers in interstitial lung diseases (ILD) to assess severity and prognosis. It is unknown whether high-resolution computed tomography pattern has any independent effect on the exercise capacity in ILD. We compar...

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Autores principales: Saxena, Puneet, Singh, Itishree, Kumar, Abhishek, Kartik, S, Malik, Virender, Tiwari, Saurabh, Akhil, KR, Pattanayak, Somali, Velangi, Vaibhavi G., Jain, Harsh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553773/
https://www.ncbi.nlm.nih.gov/pubmed/37787356
http://dx.doi.org/10.4103/lungindia.lungindia_165_23
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author Saxena, Puneet
Singh, Itishree
Kumar, Abhishek
Kartik, S
Malik, Virender
Tiwari, Saurabh
Akhil, KR
Pattanayak, Somali
Velangi, Vaibhavi G.
Jain, Harsh
author_facet Saxena, Puneet
Singh, Itishree
Kumar, Abhishek
Kartik, S
Malik, Virender
Tiwari, Saurabh
Akhil, KR
Pattanayak, Somali
Velangi, Vaibhavi G.
Jain, Harsh
author_sort Saxena, Puneet
collection PubMed
description BACKGROUND: Forced vital capacity (FVC) and six-minute walk distance (6MWD) are robust markers in interstitial lung diseases (ILD) to assess severity and prognosis. It is unknown whether high-resolution computed tomography pattern has any independent effect on the exercise capacity in ILD. We compared six-minute walk test (6MWT) parameters between usual interstitial pneumonia (UIP) and non-UIP ILD after adjusting for FVC. METHODS: Data from a tertiary care ILD clinic were retrospectively analysed. Based on HRCT, patients were classified as UIP and non-UIP. 6MWT parameters and FVC were recorded for enrolled patients. 6MWD, distance-saturation product (DSP) and exertional desaturation were compared between UIP and non-UIP, using analysis of covariance (ANCOVA), with per cent predicted FVC as covariate. Patients were grouped as mild (≥70%), moderate (51%–69%) and severe (≤50%) based on FVC severity. RESULTS: Out of 169 patients enrolled, only patients with all three data points: spirometry, 6MWT and HRCT were included in the analysis (n = 139). UIP group comprised 56 (40.3%), while non-UIP group had 83 (59.7%) patients. More females and lesser smokers were present in non-UIP group. Mean predicted FVC% was similar between the two HRCT groups (P = 0.611) and had a statistically significant, though very weak to weak correlation with 6MWT parameters {6MWD (r = 0.138); pred 6MWD% (r = 0.170); desaturation (r = -0.227); DSP index (r = 0.166)}. Analysis of covariance showed no statistically significant difference in the 6MWT parameters between UIP and non-UIP groups for similar FVC levels. CONCLUSION: For a similar level of lung function, exercise capacity was similar for patients with UIP and non-UIP pattern ILD.
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spelling pubmed-105537732023-10-06 Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study Saxena, Puneet Singh, Itishree Kumar, Abhishek Kartik, S Malik, Virender Tiwari, Saurabh Akhil, KR Pattanayak, Somali Velangi, Vaibhavi G. Jain, Harsh Lung India Original Article BACKGROUND: Forced vital capacity (FVC) and six-minute walk distance (6MWD) are robust markers in interstitial lung diseases (ILD) to assess severity and prognosis. It is unknown whether high-resolution computed tomography pattern has any independent effect on the exercise capacity in ILD. We compared six-minute walk test (6MWT) parameters between usual interstitial pneumonia (UIP) and non-UIP ILD after adjusting for FVC. METHODS: Data from a tertiary care ILD clinic were retrospectively analysed. Based on HRCT, patients were classified as UIP and non-UIP. 6MWT parameters and FVC were recorded for enrolled patients. 6MWD, distance-saturation product (DSP) and exertional desaturation were compared between UIP and non-UIP, using analysis of covariance (ANCOVA), with per cent predicted FVC as covariate. Patients were grouped as mild (≥70%), moderate (51%–69%) and severe (≤50%) based on FVC severity. RESULTS: Out of 169 patients enrolled, only patients with all three data points: spirometry, 6MWT and HRCT were included in the analysis (n = 139). UIP group comprised 56 (40.3%), while non-UIP group had 83 (59.7%) patients. More females and lesser smokers were present in non-UIP group. Mean predicted FVC% was similar between the two HRCT groups (P = 0.611) and had a statistically significant, though very weak to weak correlation with 6MWT parameters {6MWD (r = 0.138); pred 6MWD% (r = 0.170); desaturation (r = -0.227); DSP index (r = 0.166)}. Analysis of covariance showed no statistically significant difference in the 6MWT parameters between UIP and non-UIP groups for similar FVC levels. CONCLUSION: For a similar level of lung function, exercise capacity was similar for patients with UIP and non-UIP pattern ILD. Wolters Kluwer - Medknow 2023 2023-08-28 /pmc/articles/PMC10553773/ /pubmed/37787356 http://dx.doi.org/10.4103/lungindia.lungindia_165_23 Text en Copyright: © 2023 Indian Chest Society https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Saxena, Puneet
Singh, Itishree
Kumar, Abhishek
Kartik, S
Malik, Virender
Tiwari, Saurabh
Akhil, KR
Pattanayak, Somali
Velangi, Vaibhavi G.
Jain, Harsh
Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title_full Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title_fullStr Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title_full_unstemmed Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title_short Impact of HRCT pattern on six-minute walk test in patients with interstitial lung disease—An observational study
title_sort impact of hrct pattern on six-minute walk test in patients with interstitial lung disease—an observational study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553773/
https://www.ncbi.nlm.nih.gov/pubmed/37787356
http://dx.doi.org/10.4103/lungindia.lungindia_165_23
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