Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors

The complement system is the first line of innate immune defense against microbial infections. To survive in humans and cause infections, bacterial pathogens have developed sophisticated mechanisms to subvert the complement-mediated bactericidal activity. There are reports that sialidases, also know...

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Detalles Bibliográficos
Autores principales: Clark, Nicholas D., Pham, Christopher, Kurniyati, Kurni, Sze, Ching Wooen, Coleman, Laurynn, Fu, Qin, Zhang, Sheng, Malkowski, Michael G., Li, Chunhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553830/
https://www.ncbi.nlm.nih.gov/pubmed/37747935
http://dx.doi.org/10.1371/journal.ppat.1011674

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553830/
https://www.ncbi.nlm.nih.gov/pubmed/37747935
http://dx.doi.org/10.1371/journal.ppat.1011674

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