Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin

ExoY virulence factors are members of a family of bacterial nucleotidyl cyclases (NCs) that are activated by specific eukaryotic cofactors and overproduce cyclic purine and pyrimidine nucleotides in host cells. ExoYs act as actin-activated NC toxins. Here, we explore the Vibrio nigripulchritudo Mult...

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Detalles Bibliográficos
Autores principales: Teixeira Nunes, Magda, Retailleau, Pascal, Raoux-Barbot, Dorothée, Comisso, Martine, Missinou, Anani Amegan, Velours, Christophe, Plancqueel, Stéphane, Ladant, Daniel, Mechold, Undine, Renault, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553838/
https://www.ncbi.nlm.nih.gov/pubmed/37747912
http://dx.doi.org/10.1371/journal.ppat.1011654

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