Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection

Type 2 cytokines like IL-4 are hallmarks of helminth infection and activate macrophages to limit immunopathology and mediate helminth clearance. In addition to cytokines, nutrients and metabolites critically influence macrophage polarization. Choline is an essential nutrient known to support normal...

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Detalles Bibliográficos
Autores principales: Ghorbani, Peyman, Kim, Sang Yong, Smith, Tyler K. T., Minarrieta, Lucía, Robert-Gostlin, Victoria, Kilgour, Marisa K., Ilijevska, Maja, Alecu, Irina, Snider, Shayne A., Margison, Kaitlyn D., Nunes, Julia R. C., Woo, Daniel, Pember, Ciara, O’Dwyer, Conor, Ouellette, Julie, Kotchetkov, Pavel, St-Pierre, Julie, Bennett, Steffany A. L., Lacoste, Baptiste, Blais, Alexandre, Nair, Meera G., Fullerton, Morgan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553840/
https://www.ncbi.nlm.nih.gov/pubmed/37747879
http://dx.doi.org/10.1371/journal.ppat.1011658

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