Cargando…

OR11-01 A New Model for Estrogen Receptor-alpha Antagonist Mechanism of Action

Disclosure: J.C. Nwachukwu: None. J.W. Njeri: None. T. Venables: None. C. Seath: None. M.E. Pipkin: None. Y. Hou: None. B.S. Katzenellenbogen: None. J.A. Katzenellenbogen: None. K.W. Nettles: None. We recently developed Dual Mechanism Estrogen Receptor-α (ERα) Inhibitors (DMERI) with more antagonist...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nwachukwu, Jerome C, Njeri, Jacqline W, Venables, Thomas, Seath, Ciaran, Pipkin, Matthew E, Hou, Yingwei, Katzenellenbogen, Benita S, Katzenellenbogen, John A, Nettles, Kendall W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Steroid Hormones, Nuclear Receptors and Coregulators
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553947/ http://dx.doi.org/10.1210/jendso/bvad114.1734

Ejemplares similares

OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain
por: Nwachukwu, Jerome, et al.
Publicado: (2020)

OR09-2 Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets
por: Zuo, Qianying, et al.
Publicado: (2019)

SUN-028 Role of Estrogen Receptor Alpha (ERa) Acetylation in Estrogen-Dependent Gene Regulation in Breast Cancers
por: Vasquez, Yasmin, et al.
Publicado: (2019)

SUN-013 Estrogen Receptor Alpha Transactivation Function 1 Dependent Uterotropic Estrogenic Genes
por: Arao, Yukitomo, et al.
Publicado: (2019)

OR33-01 Live Cell Imaging Of Enhancer Transcriptional States
por: Chapus, Fleur, et al.
Publicado: (2023)

OR12-04 Regulatory Sharing between Estrogen Receptor Alpha Bound Enhancers
por: Gertz, Jay, et al.
Publicado: (2020)

OR22-01 Sex Differences In Enterohepatic Circulation Mediated By Hepatic FXR And SHP Depletions In Mice
por: Reichardt, Francois, et al.
Publicado: (2023)

Estrogen Receptor Alpha Is Required to Protect Daily Metabolic Rhythms From Disruption by High-Fat Feeding in Female Mice
por: Omotola, Oluwabukola B, et al.
Publicado: (2021)

THU571 Mechanisms Of Estrogen-induced Skeletal Muscle Fibrosis In An Inguinal Hernia Humanized Aromatase Mouse Model
por: Potluri, Tanvi, et al.
Publicado: (2023)

OR26-2 Phosphorylation of Estrogen Receptor Alpha is Required for Mammary Gland Development and MCF-7 Breast Tumor Response to Estradiol and Tamoxifen
por: Emneser, Waleed, et al.
Publicado: (2019)

THU575 The Canonical Wnt/β-catenin Pathway Is Not Involved In Estrogen-induced Skeletal Muscle Fibrosis In A Mouse Model Of Inguinal Hernia
por: You, Tianming, et al.
Publicado: (2023)

OR26-5 Functional Analysis of Estrogen-Regulated Enhancer RNAs in Breast Cancer Cells
por: Hou, Tim, et al.
Publicado: (2019)

SUN-005 DAX-1 Inhibition of Estrogen Receptor and Metastasis Target Genes in Estrogen Receptor Positive Breast Cancer Cells
por: Tzagarakis-Foster, Christina, et al.
Publicado: (2019)

SAT-LB005 Association of Serum Estrogens and Estrogen Metabolites with Use of Non-Steroidal Anti-Inflammatory Drugs in Postmenopausal Women
por: Fuhrman, Barbara, et al.
Publicado: (2019)

SUN-016 27-Hydroxycholesterol a Selective Estrogen Receptor Modulator: Profiling 27-Hydroxycholesterol Effects on Estrogen Receptor Activity in Mice
por: Asghari, Arvand, et al.
Publicado: (2019)

Inhibition of Estrogen Signaling Reverses Established Inguinal Hernias
por: Potluri, Tanvi, et al.
Publicado: (2021)

SAT-LB137 Rescue of Misfolded G-Protein Coupled Estrogen Receptor, GPER, from the Endoplasmic Reticulum via Natural and Synthetic Estrogens
por: Rouhimoghadam, Milad, et al.
Publicado: (2020)

OR07-1 Estrogen-regulated Enhancer RNAs Contain a Functional Motif that Controls Enhancer Assembly and Function in Breast Cancer Cells
por: Hou, Tim, et al.
Publicado: (2022)

RF03 | PMON297 Connecting Fluctuations in Estrogen Production, Release, and Action with Hormone-Dependent Gene Expression in Breast Cancers
por: Kim, Hyung Bum, et al.
Publicado: (2022)

Melanocortin 2 Receptor Antagonists in Canine Cushing’s Disease: In Vitro Studies
por: Sanders, Karin, et al.
Publicado: (2021)

SUN-733 Analysis of Divergent Long Noncoding RNAs in Estrogen-Regulated Transcription
por: Lee, Debra, et al.
Publicado: (2020)

SUN-735 Functional Analysis of Testis-Specific Noncoding Genes in Estrogen-Dependent Transcription
por: Choudhari, Ramesh, et al.
Publicado: (2020)

SUN-734 The Role of Chromatin-Associated LncRNA161 in Estrogen-Dependent Transcription
por: Le, Ilene, et al.
Publicado: (2020)

OR09-1 Estrogen Drives Atypical Cell-autonomous WNT4 Signaling In Lobular Carcinoma
por: Ferguson, Rebecca, et al.
Publicado: (2019)

OR09-4 Estrogen Sulfotransferase (EST) as a Mediator of Ischemic Acute Kidney Injury in Mice
por: Barbosa, Anne, et al.
Publicado: (2019)

SUN-748 Functional Characterization of Estrogen-Regulated LncRNA16 in ER+ Breast Cancer
por: Yang, Barbara, et al.
Publicado: (2020)

SUN-738 Establishing the Link Between Genetic Variations of Estrogen Receptor 2 and Unexplained Infertility
por: Halassy, Sophia, et al.
Publicado: (2020)

SAT-LB135 A Novel Cytoplasmic Membrane Estrogen-Mediated Biogenic Signaling Pathway
por: Pestell, Richard G
Publicado: (2020)

OR26-3 ERK1/2-RSK2 Maintains Estrogen Homeostasis in the Adult Mammary Gland
por: Sandusky, Zachary
Publicado: (2019)

SUN-LB003 The Steroid Sulfatase Dictates the Hormone Replacement Therapy Efficacy of the Conjugated Equine Estrogen
por: Feng, Ye, et al.
Publicado: (2019)

RF03 | PMON289 KLF4 drives estrogen driven tumor heterogeneity in breast cancer
por: Mohammed, Hisham, et al.
Publicado: (2022)

OR26-4 Genome-Wide Binding Profile of Phosphorylated Estrogen Receptor Reveals Association with Direct DNA Binding
por: Helzer, Kyle, et al.
Publicado: (2019)

SAT-736 Dissecting the Relative Role of Estrogen and Androgen in Fibrosis, Skeletal Muscle Atrophy, and Inguinal Hernia Formation
por: Zhao, Hong, et al.
Publicado: (2020)

OR12-05 MDC1 Is a Novel Estrogen Receptor Co-Regulator in Invasive Lobular Carcinoma of the Breast
por: Bordeaux, Evelyn K, et al.
Publicado: (2020)

RF03 | PMON302 A Unique Estrogen-Sensitive Fibroblast Population Drives Abdominal Muscle Fibrosis
por: Potluri, Tanvi, et al.
Publicado: (2022)

SUN-744 Phosphorylation Site S122 in Estrogen Receptor α Has a Tissue-Dependent Role in Female Mice
por: Gustafsson, Karin L, et al.
Publicado: (2020)

SUN-LB135 Estrogen Receptor Beta Inhibits NFkB Signaling to Inhibit Triple Negative Breast Cancer
por: Aspros, Kirsten, et al.
Publicado: (2020)

SUN-743 Understanding the Role of Pancreas and Testis Specific lncRNA86 in Estrogen-Dependent Signaling in Breast Cancer
por: Ramos, Enrique Ivan, et al.
Publicado: (2020)

SUN-739 Next Generation AR Antagonists Increase Systemic Active Glucocorticoid Exposure by Altering Glucocorticoid Metabolism
por: Alyamani, Mohammad, et al.
Publicado: (2020)

SUN-011 Identification Of Regulators Of Estrogenic Signalling In ER-positive Breast Cancer Cells By Whole Genome shRNA Screening
por: Kulpa, Justyna, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pr0odq5cjpdtv5o43raa01q66l