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THU639 17α-Estradiol Signals Primarily Through Nongenomic Mechanisms: Implications For Its Beneficial Longevity Effects

Disclosure: P.S. Cooke: None. V.K. Sirohi: None. H.D. Zomer: None. J.B. Graceli: None. A. Mesa: None. T. Medrano: None. Recent work indicates that exogenous 17α-estradiol (17α-E2), a stereoisomer of 17β-E2, increases longevity 20% in male mice, despite previous literature that 17α-E2 is a weak estro...

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Detalles Bibliográficos
Autores principales: Cooke, Paul S, Sirohi, Vijay K, Zomer, Helena D, Graceli, Jones B, Mesa, Ana, Medrano, Theresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10553984/
http://dx.doi.org/10.1210/jendso/bvad114.1543