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THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure
Disclosure: F. Bandeira: None. L.B. Oliveira: None. M.A. Siqueira: None. M.A. Litvin: None. J.M. Garcia: None. L. Bandeira: None. Introduction: Heart failure (HF) is a clinical syndrome directly associated with functional impairment, which may be interrelated with skeletal consequences and an increa...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554015/ http://dx.doi.org/10.1210/jendso/bvad114.376 |
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author | Bandeira, Francisco Oliveira, Lucian B Siqueira, Mariana A F M Litvin, Mirela A Garcia, Jessica M A Bandeira, Leonardo |
author_facet | Bandeira, Francisco Oliveira, Lucian B Siqueira, Mariana A F M Litvin, Mirela A Garcia, Jessica M A Bandeira, Leonardo |
author_sort | Bandeira, Francisco |
collection | PubMed |
description | Disclosure: F. Bandeira: None. L.B. Oliveira: None. M.A. Siqueira: None. M.A. Litvin: None. J.M. Garcia: None. L. Bandeira: None. Introduction: Heart failure (HF) is a clinical syndrome directly associated with functional impairment, which may be interrelated with skeletal consequences and an increased risk of fractures. The trabecular bone score (TBS) allows an indirect assessment of the bone microarchitecture, a helpful tool in fracture risk stratification. Objective: To evaluate the TBS and its relationship with bone mineral density (BMD) and cardiometabolic parameters in patients admitted with HF. Methods: Cross-sectional study was conducted in a Cardiology center, with patients aged 40 to 85 years hospitalized with HF. Clinical, echocardiographic, laboratory and BMD were evaluated. TBS <1.230 was characterized as bone degradation. Results: A total of 103 patients were evaluated, of which 53.4% were female. The mean age was 64.1 ± 9.4 years. The median left ventricular ejection fraction (LVEF) was 50.0% (interquartile range [IQR] 34.0-61.0%), with 50.5% having preserved LVEF (≥50%), 5.8% having mildly reduced LVEF (41-49%), and 43.7% having reduced LVEF (≤40%). 50.4% of patients had New York Heart Association Functional Classification (NYHA-FC) I-II and 49.6% NYHA-FC III-IV. The majority (67%) of patients had HF of ischemic etiology; 43.7% had diabetes mellitus and 30.0% had prediabetes. Bone degradation indicated by TBS was present in 33.0% of the sample, while BMD in the osteoporosis range was observed in 22.3%. There was no statistically significant difference between genders in the presence of bone degradation (22.9% of men vs. 36.4% of women, p = 0.138). Low TBS was associated with higher mean age (67.5 ± 9.1 vs. 62.7 ± 9.2 years, p = 0.016) and lower T-scores in the lumbar spine (−1.9 ± 1.3 vs. −0.7 ± 1,8, p = 0.001), femoral neck (−1.6 ± 1.2 vs. −1.1 ± 1.2, p = 0.030), and total femur (−1.3 ± 1.1 vs. −0.5 ± 1.3, p = 0.005). There was no association between low TBS and body mass index (28.0 ± 4.4 vs. 27.8 ± 5.3 kg/m², p = 0.828), LVEF (50.0% [30.0-59.0] vs. 55.0% [34.3-61.8], p = 0.183) and hemoglobin A1c (6.4% [5.7-7.9] vs. 6.2% [5.7-8.2], p = 0.920). Patients with NYHA-FC III-IV had lower mean TBS when compared to those with NYHA-FC I-II (1.273 ± 0.138 vs. 1.335 ± 0.149, p = 0.031). Conclusion: We found that bone microarchitecture deterioration was more frequent than osteoporosis in patients hospitalized with HF, with greater symptomatology being associated with lower TBS. Presentation: Thursday, June 15, 2023 |
format | Online Article Text |
id | pubmed-10554015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105540152023-10-06 THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure Bandeira, Francisco Oliveira, Lucian B Siqueira, Mariana A F M Litvin, Mirela A Garcia, Jessica M A Bandeira, Leonardo J Endocr Soc Bone And Mineral Metabolism Disclosure: F. Bandeira: None. L.B. Oliveira: None. M.A. Siqueira: None. M.A. Litvin: None. J.M. Garcia: None. L. Bandeira: None. Introduction: Heart failure (HF) is a clinical syndrome directly associated with functional impairment, which may be interrelated with skeletal consequences and an increased risk of fractures. The trabecular bone score (TBS) allows an indirect assessment of the bone microarchitecture, a helpful tool in fracture risk stratification. Objective: To evaluate the TBS and its relationship with bone mineral density (BMD) and cardiometabolic parameters in patients admitted with HF. Methods: Cross-sectional study was conducted in a Cardiology center, with patients aged 40 to 85 years hospitalized with HF. Clinical, echocardiographic, laboratory and BMD were evaluated. TBS <1.230 was characterized as bone degradation. Results: A total of 103 patients were evaluated, of which 53.4% were female. The mean age was 64.1 ± 9.4 years. The median left ventricular ejection fraction (LVEF) was 50.0% (interquartile range [IQR] 34.0-61.0%), with 50.5% having preserved LVEF (≥50%), 5.8% having mildly reduced LVEF (41-49%), and 43.7% having reduced LVEF (≤40%). 50.4% of patients had New York Heart Association Functional Classification (NYHA-FC) I-II and 49.6% NYHA-FC III-IV. The majority (67%) of patients had HF of ischemic etiology; 43.7% had diabetes mellitus and 30.0% had prediabetes. Bone degradation indicated by TBS was present in 33.0% of the sample, while BMD in the osteoporosis range was observed in 22.3%. There was no statistically significant difference between genders in the presence of bone degradation (22.9% of men vs. 36.4% of women, p = 0.138). Low TBS was associated with higher mean age (67.5 ± 9.1 vs. 62.7 ± 9.2 years, p = 0.016) and lower T-scores in the lumbar spine (−1.9 ± 1.3 vs. −0.7 ± 1,8, p = 0.001), femoral neck (−1.6 ± 1.2 vs. −1.1 ± 1.2, p = 0.030), and total femur (−1.3 ± 1.1 vs. −0.5 ± 1.3, p = 0.005). There was no association between low TBS and body mass index (28.0 ± 4.4 vs. 27.8 ± 5.3 kg/m², p = 0.828), LVEF (50.0% [30.0-59.0] vs. 55.0% [34.3-61.8], p = 0.183) and hemoglobin A1c (6.4% [5.7-7.9] vs. 6.2% [5.7-8.2], p = 0.920). Patients with NYHA-FC III-IV had lower mean TBS when compared to those with NYHA-FC I-II (1.273 ± 0.138 vs. 1.335 ± 0.149, p = 0.031). Conclusion: We found that bone microarchitecture deterioration was more frequent than osteoporosis in patients hospitalized with HF, with greater symptomatology being associated with lower TBS. Presentation: Thursday, June 15, 2023 Oxford University Press 2023-10-05 /pmc/articles/PMC10554015/ http://dx.doi.org/10.1210/jendso/bvad114.376 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Bone And Mineral Metabolism Bandeira, Francisco Oliveira, Lucian B Siqueira, Mariana A F M Litvin, Mirela A Garcia, Jessica M A Bandeira, Leonardo THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title | THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title_full | THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title_fullStr | THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title_full_unstemmed | THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title_short | THU415 Trabecular Bone Score In Hospitalized Patients With Heart Failure |
title_sort | thu415 trabecular bone score in hospitalized patients with heart failure |
topic | Bone And Mineral Metabolism |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554015/ http://dx.doi.org/10.1210/jendso/bvad114.376 |
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