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FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome

Disclosure: B. Bolayir: None. F. Gogus: None. B. Demir: None. M.M. Yalcin: None. J. Meray: None. A. Altinova: None. F.S. Toruner: None. M.Y. Akturk: None. Background: Myopathy, being induced by antianabolic and catabolic effects of excess corticosteroids is one of the characteristic features of Cush...

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Autores principales: Bolayir, Basak, Gogus, Feride, Demir, Beril, Yalcin, Mehmet Muhittin, Meray, Jale, Altinova, Alev, Toruner, Fusun Saadet, Akturk, Mujde Yasim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554139/
http://dx.doi.org/10.1210/jendso/bvad114.165
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author Bolayir, Basak
Gogus, Feride
Demir, Beril
Yalcin, Mehmet Muhittin
Meray, Jale
Altinova, Alev
Toruner, Fusun Saadet
Akturk, Mujde Yasim
author_facet Bolayir, Basak
Gogus, Feride
Demir, Beril
Yalcin, Mehmet Muhittin
Meray, Jale
Altinova, Alev
Toruner, Fusun Saadet
Akturk, Mujde Yasim
author_sort Bolayir, Basak
collection PubMed
description Disclosure: B. Bolayir: None. F. Gogus: None. B. Demir: None. M.M. Yalcin: None. J. Meray: None. A. Altinova: None. F.S. Toruner: None. M.Y. Akturk: None. Background: Myopathy, being induced by antianabolic and catabolic effects of excess corticosteroids is one of the characteristic features of Cushing Syndrome (CS). Muscle thickness which has been shown to be correlated with muscle cross sectional area can be used as an indicator of muscle mass. Although many studies have demonstrated effects of corticosteroids on collagen metabolism and case reports documented rupture of tendons in patients with chronic exposure to corticosteroids, tendon changes of patients with endogenous hypercortisolism have not been studied. Ultrasound, although not studied well in this group of patients, can be an alternative imaging method that provides information about muscle and tendon thickness. The aim of this study was to investigate muscle, tendon thicknesses and serum levels of myostatin in patients with CS. Methods: Twenty-two patients with CS and nineteen healthy control subjects similar for age, sex, height and weight were enrolled. Lower extremity tendon and muscle groups’ thickness were evaluated by ultrasound. Serum myostatin levels were measured by ELISA. Results: Age, height, weight and body mass index were similar between groups (p>0.05). The thicknesses of rectus femoris, vastus medialis, vastus lateralis, gastrocnemius medialis and gastrocnemius lateralis were lower in the CS group than control group (p≤0.001). However, thickness of soleus muscle was not significantly different between the groups (p > 0.05). No significant difference was revealed between groups in terms of Achilles and patellar tendon thickness (p>0.05). Median serum myostatin levels were found to be lower in the CS group than the control group (p<0.001).Conclusions: Ultrasound based measurement of muscle thickness can be used to assess and monitor steroid-induced changes of muscle mass. The fact that the thickness of the proximal muscles of lower extremity was found to be lower by ultrasound in patients with CS in our study supports the proximal myopathy feature of CS. Besides that, it was shown that the gastrocnemius lateralis and medialis thicknesses, which are the distal muscles of the lower extremity, were also shown to be lower in the Cushing group. On the other hand, CS might not affect the thickness of the lower extremity tendons. Moreover, the mechanism of the decrease in the level of myostatin, the negative regulator of muscle growth, in patients with needs to be elucidated with CS further studies. Presentation: Friday, June 16, 2023
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spelling pubmed-105541392023-10-06 FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome Bolayir, Basak Gogus, Feride Demir, Beril Yalcin, Mehmet Muhittin Meray, Jale Altinova, Alev Toruner, Fusun Saadet Akturk, Mujde Yasim J Endocr Soc Adrenal (Excluding Mineralocorticoids) Disclosure: B. Bolayir: None. F. Gogus: None. B. Demir: None. M.M. Yalcin: None. J. Meray: None. A. Altinova: None. F.S. Toruner: None. M.Y. Akturk: None. Background: Myopathy, being induced by antianabolic and catabolic effects of excess corticosteroids is one of the characteristic features of Cushing Syndrome (CS). Muscle thickness which has been shown to be correlated with muscle cross sectional area can be used as an indicator of muscle mass. Although many studies have demonstrated effects of corticosteroids on collagen metabolism and case reports documented rupture of tendons in patients with chronic exposure to corticosteroids, tendon changes of patients with endogenous hypercortisolism have not been studied. Ultrasound, although not studied well in this group of patients, can be an alternative imaging method that provides information about muscle and tendon thickness. The aim of this study was to investigate muscle, tendon thicknesses and serum levels of myostatin in patients with CS. Methods: Twenty-two patients with CS and nineteen healthy control subjects similar for age, sex, height and weight were enrolled. Lower extremity tendon and muscle groups’ thickness were evaluated by ultrasound. Serum myostatin levels were measured by ELISA. Results: Age, height, weight and body mass index were similar between groups (p>0.05). The thicknesses of rectus femoris, vastus medialis, vastus lateralis, gastrocnemius medialis and gastrocnemius lateralis were lower in the CS group than control group (p≤0.001). However, thickness of soleus muscle was not significantly different between the groups (p > 0.05). No significant difference was revealed between groups in terms of Achilles and patellar tendon thickness (p>0.05). Median serum myostatin levels were found to be lower in the CS group than the control group (p<0.001).Conclusions: Ultrasound based measurement of muscle thickness can be used to assess and monitor steroid-induced changes of muscle mass. The fact that the thickness of the proximal muscles of lower extremity was found to be lower by ultrasound in patients with CS in our study supports the proximal myopathy feature of CS. Besides that, it was shown that the gastrocnemius lateralis and medialis thicknesses, which are the distal muscles of the lower extremity, were also shown to be lower in the Cushing group. On the other hand, CS might not affect the thickness of the lower extremity tendons. Moreover, the mechanism of the decrease in the level of myostatin, the negative regulator of muscle growth, in patients with needs to be elucidated with CS further studies. Presentation: Friday, June 16, 2023 Oxford University Press 2023-10-05 /pmc/articles/PMC10554139/ http://dx.doi.org/10.1210/jendso/bvad114.165 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Adrenal (Excluding Mineralocorticoids)
Bolayir, Basak
Gogus, Feride
Demir, Beril
Yalcin, Mehmet Muhittin
Meray, Jale
Altinova, Alev
Toruner, Fusun Saadet
Akturk, Mujde Yasim
FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title_full FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title_fullStr FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title_full_unstemmed FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title_short FRI170 Ultrasound-Based Evaluation Of Muscles And Tendons In Patients With Cushing Syndrome
title_sort fri170 ultrasound-based evaluation of muscles and tendons in patients with cushing syndrome
topic Adrenal (Excluding Mineralocorticoids)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554139/
http://dx.doi.org/10.1210/jendso/bvad114.165
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