THU638 Comparison Of Body Composition Changes In Response To A Hypocaloric Dietary Intervention In Women With And Without Polycystic Ovary Syndrome

Disclosure: J. Zhang: None. F. Carter: None. B.Y. Jarrett: None. B. Drewes: None. H. Vanden Brink: None. M.E. Lujan: None. Lifestyle intervention aimed at weight loss is recommended for women with polycystic ovary syndrome (PCOS) and concurrent obesity to improve reproductive, metabolic, and psychological health and well-being. However, we and others have shown that women with PCOS have perceptions of reduced success of weight loss interventions, and futility related to adoption of healthy lifestyle practices which can affect motivation and adherence to lifestyle change. Empirical data to support reduced success of weight loss interventions in PCOS is lacking. The objective of this study was to contrast the effectiveness of a hypocaloric dietary intervention on weight loss and body composition in women with and without PCOS. Thirty-eight reproductive age females (body mass index ≥25) with (N=22) or without (N=16) PCOS partook in a 4-week baseline assessment (pre-intervention), followed by a 12-week (3MO, N=17) or 24-week (6MO, N=21) commercial hypocaloric dietary intervention. Serial weight assessments were conducted at least twice per week and dual x-ray absorptiometry (DEXA) measured body composition pre- and post-intervention. Random coefficient models were used to compare changes in weight during the intervention. Differences in body composition pre- and post-intervention and across groups were compared using linear regression and analysis of variance. Participants lost an average of 7.8±3.2% and 9.0±5.0% total body weight with the 3MO and 6MO interventions, respectively. Waist circumference (107.1 ± 14.0 vs. 96.9 ± 12.6cm, P<0.001), total lean mass (55.2 ± 7.2 vs. 51.8 ± 6.4cm, P<0.05), total fat mass (43.2 ± 9.7 vs. 38.8 ± 8.9cm, P<0.01) and trunk lean (27.1 ± 3.7 vs. 25.5 ± 3.6kg, P<0.05) and fat mass ((21.7 ± 5.7 vs. 19.6 ± 5.6kg, P<0.05) were decreased post-3MO intervention in women with PCOS, whereas only total (46.3 ± 8.2 vs. 39.4 ± 9.7kg, P<0.05) and trunk fat mass (23.3 ± 5.2 vs. 20.1 ± 6.0kg, P<0.05) were decreased post-6MO intervention in women with PCOS compared to their pre-intervention values. Percent changes in the aforementioned parameters were similar across groups with either the 3MO or 6MO intervention (P>0.05), as was the rate of weight loss (P>0.05). Women with PCOS demonstrated clinically meaningful changes in body composition in response to hypocaloric dietary interventions aimed at weight loss. Similar changes in body compositions and rate of weight loss between women with and without PCOS support comparable effectiveness of short-term hypocaloric dietary interventions in women with and without PCOS. Knowledge of comparable effectiveness to lifestyle change may aid in adoption and adherence to lifestyle interventions in women with PCOS. Presentation: Thursday, June 15, 2023