Cargando…

OR05-04 Growth Hormone Receptor Antagonism Markedly Improves Therapeutic Response In Mouse Models Of Melanoma, Liver Cancer, Pancreatic Cancer And Cholangiocarcinoma

Disclosure: R. Basu: None. P. Kulkarni: None. S. Duran Ortiz: None. E. Davis: None. J.J. Kopchick: None. A major hurdle in tackling cancer, the second biggest cause of human mortality, is resistance to therapy. Human growth hormone (GH) mediated activation of the growth hormone receptor (GHR) promot...

Descripción completa

Detalles Bibliográficos
Autores principales:	Basu, Reetobrata, Kulkarni, Prateek, Ortiz, Silvana Duran, Davis, Emily, Kopchick, John Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Tumor Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554295/ http://dx.doi.org/10.1210/jendso/bvad114.2190

Ejemplares similares

Growth Hormone Receptor Inhibition Sensitizes Human Pancreatic Cancer to Chemotherapy Treatments
por: Basu, Reetobrata, et al.
Publicado: (2021)

Effects of Growth Hormone on Pancreatic Cancer Derived Exosomes
por: Kulkarni, Prateek, et al.
Publicado: (2021)

THU549 Targeting The Growth Hormone Receptor Attenuates Tumor Exosome Mediated Propagation Of Chemoresistance In Melanoma
por: Kulkarni, Prateek, et al.
Publicado: (2023)

SAT-LB053 Investigating the Effects of Growth Hormone on Tumor-derived Exosome Output and Content
por: Kulkarni, Prateek, et al.
Publicado: (2019)

Effects of Growth Hormone in Human Melanoma Drug Resistance
por: Arora, Pranay, et al.
Publicado: (2021)

SUN-336 Autocrine / Paracrine Growth Hormone (GH) Drives Multimodal Therapy Resistance in Growth Hormone Receptor (GHR)-expressing Human Cancers
por: Basu, Reetobrata, et al.
Publicado: (2019)

SAT-LB054 Growth Hormone Receptor (GHR) Antagonism Suppresses Hepatocellular Carcinoma Growth in a Syngeneic Mouse Model
por: Mathes, Samuel, et al.
Publicado: (2019)

THU545 Growth Hormone Receptor Antagonist As A Novel Combination Therapy Against Triple Negative Breast Cancer
por: Mora-Criollo, Patricia, et al.
Publicado: (2023)

MON-311 GH Action Upregulates ABC Transporters And EMT Markers In A Syngeneic Melanoma Mouse Model
por: Qian, Yanrong, et al.
Publicado: (2019)

The effects of growth hormone on therapy resistance in cancer
por: Basu, Reetobrata, et al.
Publicado: (2019)

Growth hormone receptor antagonism downregulates ATP-binding cassette transporters contributing to improved drug efficacy against melanoma and hepatocarcinoma in vivo
por: Basu, Reetobrata, et al.
Publicado: (2022)

Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways
por: Basu, Reetobrata, et al.
Publicado: (2017)

Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo
por: Qian, Yanrong, et al.
Publicado: (2020)

OR0304 Novel Dual Antagonists Of The Growth Hormone Receptor And The Prolactin Receptor
por: Basu, Reetobrata, et al.
Publicado: (2023)

SAT-181 Characterization of Adult Growth Hormone Receptor Gene-Disrupted Mice
por: Duran-Ortiz, Silvana, et al.
Publicado: (2019)

A Novel Peptide Antagonist of the Human Growth Hormone Receptor
por: Basu, Reetobrata None, et al.
Publicado: (2021)

Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma
por: Basu, Reetobrata, et al.
Publicado: (2019)

A novel peptide antagonist of the human growth hormone receptor
por: Basu, Reetobrata, et al.
Publicado: (2021)

OR05-04 Steroid Receptor Co-Activators Complexes Cooperate with Progesterone Receptors (PR) to Reprogram Metabolic Pathways that Drive Therapy Resistant Populations in ER+ Breast Cancer
por: Truong, Thu H, et al.
Publicado: (2020)

Growth hormone receptor gene disruption in mature‐adult mice improves male insulin sensitivity and extends female lifespan
por: Duran‐Ortiz, Silvana, et al.
Publicado: (2021)

Structure and function of a dual antagonist of the human growth hormone and prolactin receptors with site-specific PEG conjugates
por: Basu, Reetobrata, et al.
Publicado: (2023)

SAT-041 Bioinformatic Analysis of Human Cutaneous Melanomas Identifies Increased Mortality and Genetic Alterations in GH-responsive Tumors
por: Kruse, Colin P.S., et al.
Publicado: (2019)

OR05-05 A Novel Model Of Prostate Cancer Suggests Enzalutamide Functions Through The Immune System To Diminish Castration Resistant And Metastatic Growth
por: Kregel, Steven
Publicado: (2023)

OR05-05 Lethal ERα-Dependent Hyperactivation of the Unfolded Protein Response Induces Complete Regression Without Recurrence of Primary and Metastatic Breast Cancer
por: Duraki, Darjan, et al.
Publicado: (2020)

RF05 | PSUN341 Role of sirtuins in breast cancer cells response to Fulvestrant
por: Sengupta, Surojeet, et al.
Publicado: (2022)

Growth Hormone Receptor Gene Disruption in Mature-Adult Mice Improves Glucose Metabolism and Lifespan in Females
por: Duran-Ortiz, Silvana, et al.
Publicado: (2021)

OR05-06 The Androgen Receptor Is a Tumour Suppressor in Estrogen Receptor Positive Breast Cancer
por: Hickey, Theresa E, et al.
Publicado: (2020)

OR16-05 25-Hydroxycholesterol Mediates The Effects Of Dyslipidemia On Triple Negative Breast Cancer Metastasis
por: Etella, Abora, et al.
Publicado: (2023)

OR16-04 Androgen Deprivation Restricts Anti-tumor Immunity In Adrenocortical Carcinoma
por: Warde, Kate M, et al.
Publicado: (2023)

OR05-02 The IGFBP-3/IGFBP-3 Receptor Axis Is a New Therapeutic Target for Triple Negative Breast Cancer
por: Cai, Qing, et al.
Publicado: (2020)

OR05-02 Silencing Of Adenylosuccinate Lyase Impairs Growth And Perturbs Mitochondrial Function Of Endocrine Therapy Resistant Breast Cancer Cells
por: Yadav, Anil K, et al.
Publicado: (2023)

The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies
por: Duran-Ortiz, Silvana, et al.
Publicado: (2017)

Staging Laparoscopy for Hilar Cholangiocarcinoma: Is it Still Worthwhile?
por: Ruys, Anthony T., et al.
Publicado: (2011)

Eligibility for Liver Transplantation in Patients with Perihilar Cholangiocarcinoma
por: Vugts, Jaynee J. A., et al.
Publicado: (2020)

SAT033 Disruption Of GHR In “Middle Aged” Mice Enhances Insulin Sensitivity And Extends Male Lifespan
por: Duran-Ortiz, Silvana, et al.
Publicado: (2023)

RF05 | PSUN358 ANPEP: A potential regulator of tumor cell - macrophage metabolic interactions in prostate cancer of African American men
por: Yamoah, Kosj, et al.
Publicado: (2022)

OR05-03 Treatment Of Parathyroid Neoplasia By Pharmacologic cdk4/6 Inhibition
por: Costa-Guda, Jessica, et al.
Publicado: (2023)

Comparison of the Sixth and the Seventh Editions of the UICC Classification for Perihilar Cholangiocarcinoma
por: Juntermanns, Benjamin, et al.
Publicado: (2012)

MON-312 Biochemical Basis of Steroid Hormones Action on Human Melanoma Cell Growth In-Vitro and Its Clinical Implication
por: Ramaraj, Pandurangan
Publicado: (2019)

OR05-01 Small Heterodimer Partner Modulates Antigen Presenting Myeloid Cells to Impair Regulatory T Cell Expansion, Promoting Anti-Tumor Immunity in Models of Breast Cancer
por: Shahoei, Sayyed Hamed, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ggsrpoohtontg1jvrepvhfce2l