FRI404 CNS Manifestations Are Linked With Hot Flashes: Analysis Of Real World Data From A Social Network

Disclosure: S. Shaklai: None. Y. Greenman: None. E. Yom-Tov: None. Background: Hot flashes, a hallmark of the menopausal transition, frequently coincides with CNS manifestations of disturbed sleep, cognition, and mood. How these relate is an active area of research. Objective: To evaluate the association of hot flashes with specific CNS manifestations, as expressed by women on one of the largest social media platforms (Reddit). Methods: We downloaded 4772 posts from Reddit’s Menopause group. 586 randomly sampled posts were labelled for their relevancy to menopause. Relevant posts were further labelled for mentions of hot flashes, cognition, reports of adverse mood, sleep problems and reported age. A random forest model for identifying relevant posts from words and bigrams of the posts was trained using the labelled samples and its performance evaluated using 10-fold cross-validation. The model reached an Area Under Curve (AUC) of 0.77. The model was used to filter the remaining posts by selecting posts classified as having a 75% or more likelihood of being about menopause\perimenopause. This resulted in 3546 posts from 1854 users. Models for the remaining labels were trained, reaching AUCs of 0.70 to 0.79. The models were applied to the unlabeled posts. Labels with a prediction in the range of 33-66% were removed to keep only those for which models provided strong indications. Posts were aggregated by user and the average score for each predicted label was computed. Main Outcome Measures: The ratio of women reporting one of three outcomes; disturbances in cognition, mood, or sleep, from all women with or without hot flashes. Results: The average stated age was 44.3 years (range: 21-59, N=165). In the whole cohort, hot flashes were reported in 32%, adverse mood in 40%, impaired sleep in18% and cognitive disruption in 15% of women. In women with hot flashes, adverse mood occurred in 46.9%, impaired sleep in 27.2%, and cognitive disruption in 25.3%. In women without hot flashes adverse mood occurred in 4.3%, impaired sleep in 0.7% and cognitive disruption in 0.7%. Results are statistically significant (chi2 test) at P<10^(-10). Conclusions: Hot flashes, which occurred in a third of the women, were individually associated with disturbances in mood, sleep and cognition. Adverse mood was highly prevalent and should be actively sought and addressed. Presentation: Friday, June 16, 2023