THU602 A Comprehensive Review Of Incidence, Demographics, Laterality And Survival Analysis Of Adrenal Malignancies.

Disclosure: K. Desai: None. K. Pereira: None. S. Iqbal: None. B. Baralo: None. M. Vidhi: None. M. Renzu: None. M. Rather: None. R. Thirumaran: None. Background: Adrenal malignancy is extremely rare in the United States with only ∼200 new cases/per year. Adrenocortical carcinoma is the most common histologic subtype, followed by pheochromocytoma and neuroblastoma. In this study, our aim is to evaluate the incidence rate and compare the survival analysis based on race, laterality, and histologic tissue involvement. Method: The data were collected from Surveillance, Epidemiology, and End Result database 17 Registries, Nov 2021 Sub (2000-2019). We included patients above 20 years with a primary diagnosis of an adrenal malignant tumor. Neuroblastomas were excluded due to low incidence in the adult population. We analyzed incidence rates using linear regression with t-test and compared overall survival (OS) curves using the Log-rank test (GraphPad Prism). Result: 3323 cases were identified with the majority being female (54.68%). 50.29% were adrenal cortical tumors, followed by pheochromocytoma (14.44%) & neuroblastoma (0.51%). 48.03% were left-sided, 39.54% were right-sided, 3.64% were bilateral & the rest were unspecified. The incidence rate for adrenal tumors is 2.77 per 1 million. The highest incidence was among Caucasians (2.98), followed by African American (2.63, p=0.09), which is higher than Asians (2.03, p<0.0001) and Hispanics (2.42, p=0.0002). A review of the incidence trends showed that only African-American patients had rising incidence rates from 1.46 in 2000 to 2.48 in 2019 (p=0.02). Patients with adrenal cortical tumors had worse survival compared to patients with pheochromocytoma (19 vs 98 months) HR 2.236 [1.988-2.232]. No significant statistical difference was noticed in the survival of left vs. right-sided tumors or racial groups when subdivided based on histology. However, there was a difference in the median survival of the women with pheochromocytoma (123m), compared to men (75m) HR 1.397 [1.064 - 1.834]. Conclusion: The incidence rate of adrenal malignancies remained stable and is higher among Caucasians compared to Hispanics and Asians. We noticed concerning rising incidence among African American patients. Patients with adrenocortical tumors had worse survival compared to patients with pheochromocytoma. Laterality of the tumor and race of the patients plays no role in survival in adrenal malignancies, unlike the colon and kidneys. However, there is a noticeably lower survival of the male population with pheochromocytoma. Presentation: Thursday, June 15, 2023