THU245 Association Between Sleep Duration And Incident Diabetes Mellitus In Healthy Subjects: A 12-year Longitudinal Cohort Study

Disclosure: W. Kim: None. J. Huh: None. Objective: Previous studies demonstrated that inadequate sleep, including the deprivation of absolute sleep duration and poor sleep quality, was associated with a higher risk of type 2 diabetes mellitus (DM) and obesity. This study aimed to investigate whether sleep duration and/or quality is associated with incident DM. Methods: The study population consisted of participants in the ongoing Korean Genome and Epidemiology Study (KoGES)-Ansung and Ansan Cohort Study, a rural, community-based, prospective study. A total of 8,816 of 10,030 healthy participants were enrolled in a prospective cohort study. DM was diagnosed as fasting glucose ≥126 mg/dL or 2-h post-loading glucose ≥200 mg/dL. Sleep du-ration and quality questionnaires were completed. Sleep duration was classified into four groups: 6 <, 6-7, 8-9, 9 h/day. Sleep quality was assessed in participants with sleep duration of < 10 h/day using the Epworth Sleepiness Scale (ESS) which measures an excessive daytime sleepiness in individuals. Results: During the 14-year follow-up period, 18% (1630/8816) were diagnosed with DM. A U-shaped relationship was observed between sleep duration and incident DM, with the highest risk observed when sleep duration was 10 ≥ h/day (Hazard ratios (HR) 1.65 [1.25–2.17]). This group exhibited decreased insulin glycogenic index, a marker of insulin secretory function, during the study period. Among study participants who slept less than 10 h/day, the risk of incident DM increased when the ESS score was > 10. Conclusion: We found that the association between sleep duration and incident DM was U-shaped; both short (≤5 h) and long (≥10 h) sleep duration were associated with an increased risk for the occurrence of incident DM. When sleep duration was 10 h or longer per day, there was a tendency to develop DM due to decreased insulin secretory function. Even if the sleep duration is less than 10 h, the likelihood of developing diabetes is greater when the quality of sleep decreases. Presentation: Thursday, June 15, 2023