SAT088 Poor Sleep Quality And Insufficient Sleep Duration Are Common In Maturity Onset Diabetes Of The Young

Disclosure: M.A. Arosemena: None. K. Wroblewski: None. E. Tasali: None. L. Philipson: Research Investigator; Self; Novo Nordisk, Novartis Pharmaceuticals. Background: Poor sleep quality and insufficient sleep duration are highly common in type 1 and type 2 diabetes. Maturity Onset Diabetes of the Young (MODY) is a unique form of diabetes that is usually characterized by patients being lean, not using insulin, or using diabetes-related technology. This subpopulation has not been studied in regards to their sleep patterns. Objective: To evaluate objective and subjective sleep patterns and their association with glycemic variability in adults with MODY. Methods: Adults with MODY were recruited from the Monogenic Diabetes Registry at the University of Chicago. Subjective sleep quality was measured by a validated survey, the Pittsburgh Sleep Quality Index (PSQI), and sleep patterns were objectively assessed at home by wrist-worn accelerometry (Fitbit Inspire 2) for two consecutive weeks. Glycemic variability was assessed by 2 weeks of continuous glucose monitoring (CGM). Results: To date, a total of 51 patients completed the study. Participants (age:46 ± 12.4 years; BMI:24.6 ± 3.5 kg/m(2), diabetes duration: 22.6 ± 13.5, HbA1c: 6.3 ±0.6%) were mostly white (84%), premenopausal (68%), and female (74%). Pathogenic variants included 51% GCK-MODY, 25% HNF1A-MODY, 16% HNF4A-MODY, and 8% HNF1B-MODY. Most participants (71%) reported engaging in regular exercise ( i.e., exercising more than twice and accumulating at least 90 min of moderate or 40 min of vigorous activity in an average week), 45% were only on diet and exercise as their diabetes therapy and 20% were on insulin. Only 27% were on diabetes-related technology (insulin pump and/or CGM) and 88% had no diabetes-related complications. Based on accelerometry (630 nights of analyzed Fitbit data; n=45) 39% of patients had a sleep duration of <7 hours, below the healthy adult recommendations, 90% had a wake after sleep onset (WASO) >40 minutes (normative criteria ≤40 minutes) and, 14% had a sleep efficiency <85% (normative criteria ≥85%)Most patients (69%) reported poor sleep quality with a PSQI mean score of 7.2±3.3 (a score of >5 reflecting poor sleep quality). The data analyses on the association between sleep and glycemic patterns (from CGM) are ongoing. Conclusion: Poor subjective and objective sleep quality and insufficient objective sleep duration are common among MODY patients despite most of them being lean, not on insulin or using diabetes-related technology. Further research should investigate sleep-glycemia relationship in this unique diabetes population. Presentation: Saturday, June 17, 2023