FRI616 Combined Elf5a And Notch Inhibition Reprograms The Effector T Cell Fate Decisions Towards Treg Phenotype Without Any Off Target Effect

Disclosure: S. Rafiqi: None. A. Aldasouqi: None. S. faisal: None. S. Qureshi: None. A. Mahmood: None. J.C. Jaume: None. S. Imam: None. We explored immune resetting and plasticity of T effector cells towards T regulatory cells (CD4+CD25+FOXP3+) by elF5A and Notch inhibition. We validated our approach...

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Detalles Bibliográficos
Autores principales: Imtiaz Rafiqi, Shafiya, Aldasouqi, Ahmad, faisal, sarah, Qureshi, Salauddin, Mahmood, Asif, Carlos Jaume, Juan, Imam, Shahnawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Diabetes And Glucose Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10554708/
http://dx.doi.org/10.1210/jendso/bvad114.838

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